产品名称
EFS Rabbit Polyclonal Antibody
别名
Embryonal Fyn-associated substrate (hEFS) (Cas scaffolding protein family member 3)
存储缓冲液
Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.86% New type preservative N.
Human Gene Link
https://www.uniprot.org/uniprot/10278
Human Swissprot No.
O43281
Human Swissprot Link
https://www.uniprot.org/uniprotkb/O43281/entry
Mouse Gene Link
https://www.uniprot.org/uniprot/13644
Mouse Swissprot No.
Q64355
Mouse Swissprot Link
https://www.uniprot.org/uniprotkb/Q64355
免疫原
Synthesized peptide derived from human EFS AA range: 108-158
特异性
This antibody detects endogenous levels of EFS at Human/Mouse
宿主
Polyclonal, Rabbit,IgG
背景介绍
The longest protein isoform encoded by this gene contains an SH3 domain, which is known to be important in intracellular signal transduction. The protein encoded by a similiar gene in mice was shown to bind to SH3 domains of protein-tyrosine kinases. The function of this gene is unknown. Three alternatively spliced variants encoding different isoforms have been described for this gene. [provided by RefSeq, Mar 2013],
组织表达
The protein has been detected in lung and placenta.
功能
domain:Contains a central domain (substrate domain) containing multiple potential SH2-binding sites and a C-terminal domain containing a divergent helix-loop-helix (HLH) motif. The SH2-binding sites putatively bind CRK, NCK and ABL SH2 domains.,domain:The SH3-binding sites that bind to the SRC SH3 domain are required for interaction with CRK and are implicated in promotion of serum response element (SRE) activation. The SH3 domain interacts with focal adhesion kinase 1.,function:Docking protein which plays a central coordinating role for tyrosine-kinase-based signaling related to cell adhesion. May serve as an activator of SRC and a downstream effector. Interacts with the SH3 domain of FYN and with CRK, SRC, and YES.,PTM:Phosphorylated on multiple tyrosine residues. Phosphorylated on tyrosines by FYN and SRC.,similarity:Belongs to the CAS family.,similarity:Contains 1 SH3 domain.,tissue specificity:The protein has been detected in lung and placenta.,
纯化
The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
