产品名称
SAFB2 Rabbit Polyclonal Antibody
别名
Scaffold attachment factor B2 (SAF-B2)
存储缓冲液
Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.226% New type preservative N.
Human Gene Link
https://www.uniprot.org/uniprot/9667
Human Swissprot No.
Q14151
Human Swissprot Link
https://www.uniprot.org/uniprotkb/Q14151/entry
Mouse Gene Link
https://www.uniprot.org/uniprot/224902
Mouse Swissprot No.
Q80YR5
Mouse Swissprot Link
https://www.uniprot.org/uniprotkb/Q80YR5
免疫原
Synthesized peptide derived from human SAFB2 AA range: 737-787
特异性
This antibody detects endogenous levels of SAFB2 at Human/Mouse
宿主
Polyclonal, Rabbit,IgG
背景介绍
The protein encoded by this gene, along with its paralog (scaffold attachment factor B1), is a repressor of estrogen receptor alpha. The encoded protein binds scaffold/matrix attachment region (S/MAR) DNA and is involved in cell cycle regulation, apoptosis, differentiation, the stress response, and regulation of immune genes. [provided by RefSeq, May 2016],
组织表达
Expressed at high levels in the CNS and at low levels in the liver. Expressed in a wide number of breast cancer cell lines.
功能
function:Binds to scaffold/matrix attachment region (S/MAR) DNA. Can function as an estrogen receptor corepressor and can also inhibit cell proliferation.,PTM:Phosphorylated upon DNA damage, probably by ATM or ATR.,similarity:Contains 1 RRM (RNA recognition motif) domain.,similarity:Contains 1 SAP domain.,subunit:Interacts with SAFB/SAFB1 and SCAM1.,tissue specificity:Expressed at high levels in the CNS and at low levels in the liver. Expressed in a wide number of breast cancer cell lines.,
纯化
The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
