产品名称
CD223 Rabbit Polyclonal Antibody
别名
LAG3; FDC; Lymphocyte activation gene 3 protein; LAG-3; Protein FDC; CD223
蛋白名称
Lymphocyte activation gene 3 protein
存储缓冲液
Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% New type preservative N.
Human Gene Link
http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=3902
Human Swissprot No.
P18627
Human Swissprot Link
http://www.uniprot.org/uniprotkb/P18627/entry
Mouse Gene Link
http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=16768
Mouse Swissprot No.
Q61790
Mouse Swissprot Link
http://www.uniprot.org/uniprot/Q61790
Rat Gene Link
http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=297596
Rat Swissprot Link
http://www.uniprot.org/uniprot/Q5BK54
免疫原
The antiserum was produced against synthesized peptide derived from the Internal region of human LAG3. AA range:91-140
特异性
CD223 Polyclonal Antibody detects endogenous levels of CD223 protein.
稀释度
WB 1:500 - 1:2000. ELISA: 1:20000. Not yet tested in other applications.
宿主
Polyclonal, Rabbit,IgG
背景介绍
Lymphocyte-activation protein 3 belongs to Ig superfamily and contains 4 extracellular Ig-like domains. The LAG3 gene contains 8 exons. The sequence data, exon/intron organization, and chromosomal localization all indicate a close relationship of LAG3 to CD4. [provided by RefSeq, Jul 2008],
组织表达
Primarily expressed in activated T-cells and a subset of natural killer (NK) cells.
细胞定位
[Lymphocyte activation gene 3 protein]: Cell membrane ; Single-pass type I membrane protein .; [Secreted lymphocyte activation gene 3 protein]: Secreted . Produced following cleavage of the main chain. .
功能
function:Involved in lymphocyte activation. Binds to HLA class-II antigens.,similarity:Contains 1 Ig-like V-type (immunoglobulin-like) domain.,similarity:Contains 3 Ig-like C2-type (immunoglobulin-like) domains.,tissue specificity:On cell surface of activated NK and T-lymphocytes.,
纯化
The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
