产品名称
CD239 Rabbit Polyclonal Antibody
别名
BCAM; LU; MSK19; Basal cell adhesion molecule; Auberger B antigen; B-CAM cell surface glycoprotein; F8/G253 antigen; Lutheran antigen; Lutheran blood group glycoprotein; CD239
蛋白名称
Basal cell adhesion molecule
存储缓冲液
Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% New type preservative N.
Human Gene Link
http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=4059
Human Swissprot No.
P50895
Human Swissprot Link
http://www.uniprot.org/uniprotkb/P50895/entry
Mouse Gene Link
http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=57278
Mouse Swissprot No.
Q9R069
Mouse Swissprot Link
http://www.uniprot.org/uniprot/Q9R069
Rat Gene Link
http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=78958
Rat Swissprot Link
http://www.uniprot.org/uniprot/Q9ESS6
免疫原
The antiserum was produced against synthesized peptide derived from the Internal region of human BCAM. AA range:191-240
特异性
CD239 Polyclonal Antibody detects endogenous levels of CD239 protein.
稀释度
WB 1:500 - 1:2000. ELISA: 1:20000. Not yet tested in other applications.
宿主
Polyclonal, Rabbit,IgG
背景介绍
This gene encodes Lutheran blood group glycoprotein, a member of the immunoglobulin superfamily and a receptor for the extracellular matrix protein, laminin. The protein contains five extracellular immunoglobulin domains, a single transmembrane domain, and a short C-terminal cytoplasmic tail. This protein may play a role in epithelial cell cancer and in vaso-occlusion of red blood cells in sickle cell disease. Polymorphisms in this gene define some of the antigens in the Lutheran system and also the Auberger system. Inactivating variants of this gene result in the recessive Lutheran null phenotype, Lu(a-b-), of the Lutheran blood group. Two transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, May 2012],
组织表达
Wide tissue distribution (highest in the pancreas and very low in brain). Closely associated with the basal layer of cells in epithelia and the endothelium of blood vessel walls.
细胞定位
Membrane; Single-pass type I membrane protein.
功能
cell adhesion,?cell-matrix adhesion,?biological adhesion,?cell-substrate adhesion,
纯化
The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
