产品名称
CD300f Rabbit Polyclonal Antibody
别名
CD300LF; CD300F; CLM1; IGSF13; IREM1; NKIR; CMRF35-like molecule 1; CLM-1; CD300 antigen-like family member F; Immune receptor expressed on myeloid cells 1; IREM-1; Immunoglobulin superfamily member 13; IgSF13; NK inhibitory receptor; CD300f
蛋白名称
CMRF35-like molecule 1
存储缓冲液
Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% New type preservative N.
Human Gene Link
http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=146722
Human Swissprot No.
Q8TDQ1
Human Swissprot Link
http://www.uniprot.org/uniprotkb/Q8TDQ1/entry
Mouse Gene Link
http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=246746
Mouse Swissprot No.
Q6SJQ7
Mouse Swissprot Link
http://www.uniprot.org/uniprot/Q6SJQ7
Rat Gene Link
http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=287818
Rat Swissprot Link
http://www.uniprot.org/uniprot/Q566E6
免疫原
The antiserum was produced against synthesized peptide derived from the Internal region of human CD300LF. AA range:41-90
特异性
CD300f Polyclonal Antibody detects endogenous levels of CD300f protein.
稀释度
WB 1:500 - 1:2000. IHC-p: 1:100-1:300. ELISA: 1:20000.. IF 1:50-200
宿主
Polyclonal, Rabbit,IgG
背景介绍
This gene encodes a member of the CD300 protein family. Members of this family are cell surface glycoproteins with a single IgV-like extracellular domain, and are involved in the regulation of immune response. The encoded protein is an inhibitory receptor. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Jan 2014],
组织表达
Highly expressed in spleen, peripheral blood leukocyte and monocyte, and lung. Weakly expressed in thymus, heart, brain, placenta, liver, skeletal muscle, kidney, pancreas, prostate, testis, ovary, small intestine or colon. Expressed selectively in monocytes and monocyte-related cells.
细胞定位
Cell membrane ; Single-pass type I membrane protein .
功能
function:Acts as an inhibitory receptor for myeloid cells and mast cells. Inhibits osteoclast formation.,PTM:Phosphorylated on tyrosine.,similarity:Belongs to the CD300 family.,similarity:Contains 1 Ig-like V-type (immunoglobulin-like) domain.,subunit:Interacts with PTPN6/SHP-1 in a tyrosine phosphorylation dependent manner.,tissue specificity:Highly expressed in spleen, peripheral blood leukocte and monocyte, and lung. Weakly expressed in thymus, heart, brain, placenta, liver, skeletal muscle, kidney, pancreas, prostate, testis, ovary, small intestine or colon. Expressed selectively in monocytes and monocyte-related cells.,
纯化
The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
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