产品名称
SNRPN Rabbit Polyclonal Antibody
别名
SNRPN; HCERN3; SMN; Small nuclear ribonucleoprotein-associated protein N; snRNP-N; Sm protein D; Sm-D; Sm protein N; Sm-N; SmN; Tissue-specific-splicing protein
蛋白名称
Small nuclear ribonucleoprotein-associated protein N
存储缓冲液
Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% New type preservative N.
Human Gene Link
http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=6638
Human Swissprot No.
P63162
Human Swissprot Link
http://www.uniprot.org/uniprotkb/P63162/entry
Mouse Gene Link
http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=20646
Mouse Swissprot No.
P63163
Mouse Swissprot Link
http://www.uniprot.org/uniprot/P63163
Rat Gene Link
http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=81781
Rat Swissprot Link
http://www.uniprot.org/uniprot/P63164
免疫原
The antiserum was produced against synthesized peptide derived from the Internal region of human SNRPN. AA range:21-70
特异性
SNRPN Polyclonal Antibody detects endogenous levels of SNRPN protein.
稀释度
WB 1:500-2000;IHC-p 1:50-300
宿主
Polyclonal, Rabbit,IgG
背景介绍
The protein encoded by this gene is one polypeptide of a small nuclear ribonucleoprotein complex and belongs to the snRNP SMB/SMN family. The protein plays a role in pre-mRNA processing, possibly tissue-specific alternative splicing events. Although individual snRNPs are believed to recognize specific nucleic acid sequences through RNA-RNA base pairing, the specific role of this family member is unknown. The protein arises from a bicistronic transcript that also encodes a protein identified as the SNRPN upstream reading frame (SNURF). Multiple transcription initiation sites have been identified and extensive alternative splicing occurs in the 5' untranslated region. Additional splice variants have been described but sequences for the complete transcripts have not been determined. The 5' UTR of this gene has been identified as an imprinting center. Alternative splici
组织表达
Expressed in brain and lymphoblasts.
功能
disease:Patients with the autoimmune disease systemic lupus erythematosus (SLE) have autoantibodies directed against some of the individual snRNP polypeptides. The most common autoantigen is called Sm. N bears Sm epitopes.,function:May be involved in tissue-specific alternative RNA processing events.,miscellaneous:Encoded on a bicistronic transcript that encode for two proteins, SNRPN and SNURF.,miscellaneous:Encoded on a bicistronic transcript that encode for two proteins, SNRPN and SNURF. In addition to the primary 1.6-kb bicistronic SNURF-SNRPN transcript, SNURF-only transcript is also detected.,similarity:Belongs to the snRNP SmB/SmN family.,similarity:Belongs to the SNURF family.,subunit:Interacts with TDRD3.,tissue specificity:Expressed in brain and lymphoblasts.,tissue specificity:Expressed in heart, skeletal muscle and lymphoblasts (at protein level). Expressed in brain, pancreas, heart, liver, lung, kidney and skeletal muscle.,
纯化
The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
