产品名称
MCM6 Rabbit Polyclonal Antibody
别名
MCM6; DNA replication licensing factor MCM6; p105MCM
蛋白名称
DNA replication licensing factor MCM6
存储缓冲液
Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% New type preservative N.
Human Gene Link
http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=4175
Human Swissprot No.
Q14566
Human Swissprot Link
http://www.uniprot.org/uniprotkb/Q14566/entry
Mouse Gene Link
http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=17219
Mouse Swissprot No.
P97311
Mouse Swissprot Link
http://www.uniprot.org/uniprot/P97311
Rat Swissprot Link
http://www.uniprot.org/uniprot/Q62724
免疫原
The antiserum was produced against synthesized peptide derived from the Internal region of human MCM6. AA range:331-380
特异性
MCM6 Polyclonal Antibody detects endogenous levels of MCM6 protein.
稀释度
WB 1:500-2000;IHC-p 1:50-300
宿主
Polyclonal, Rabbit,IgG
背景介绍
The protein encoded by this gene is one of the highly conserved mini-chromosome maintenance proteins (MCM) that are essential for the initiation of eukaryotic genome replication. The hexameric protein complex formed by the MCM proteins is a key component of the pre-replication complex (pre_RC) and may be involved in the formation of replication forks and in the recruitment of other DNA replication related proteins. The MCM complex consisting of this protein and MCM2, 4 and 7 proteins possesses DNA helicase activity, and may act as a DNA unwinding enzyme. The phosphorylation of the complex by CDC2 kinase reduces the helicase activity, suggesting a role in the regulation of DNA replication. Single nucleotide polymorphisms in the intron regions of this gene are associated with differential transcriptional activation of the promoter of the neighboring lactase gene and, thereby, i
细胞定位
Nucleus . Chromosome . Binds to chromatin during G1 and detach from it during S phase. .
信号通路
DNA replication;Cell_Cycle_G1S;Cell_Cycle_G2M_DNA;
功能
function:May be involved in the control of a single round of DNA replication during S phase. Binds to chromatin during G1 and detach from it during S phase as if it licenses the chromatin to replicate.,polymorphism:Intronic variations in MCM6 upstream from the LCT gene are associated with adult-type hypolactasia [MIM:223100] leading to lactose intolerance, or with lactase persistance. Lactose intolerance is a normal physiological phenomenon caused by developmental down-regulation of lactase activity during childhood or early adulthood. A non-coding variation in MCM6 affects the transcriptional regulation of the LCT gene resulting in down-regulation of lactase activity. However the majority of Northern Europeans and some African populations have the ability to maintain lactase activity and digest lactose throughout life (lactase persistence).,PTM:Phosphorylated upon DNA damage, probably by ATM or ATR.,similarity:Belongs to the MCM family.,similarity:Contains 1 MCM domain.,subunit:May interact with MCM10. Interacts with TIPIN.,
纯化
The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
