产品名称
KLK1 Rabbit Polyclonal Antibody
别名
KLK1; Kallikrein-1; Kidney/pancreas/salivary gland kallikrein; Tissue kallikrein
存储缓冲液
Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% New type preservative N.
Human Gene Link
http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=3816
Human Swissprot No.
P06870
Human Swissprot Link
http://www.uniprot.org/uniprotkb/P06870/entry
Mouse Swissprot No.
P15947
Mouse Swissprot Link
http://www.uniprot.org/uniprot/P15947
免疫原
The antiserum was produced against synthesized peptide derived from the Internal region of human KLK1. AA range:81-130
特异性
KLK1 Polyclonal Antibody detects endogenous levels of KLK1 protein.
稀释度
WB 1:500-2000;IHC-p 1:50-300
宿主
Polyclonal, Rabbit,IgG
背景介绍
Kallikreins are a subgroup of serine proteases having diverse physiological functions. Growing evidence suggests that many kallikreins are implicated in carcinogenesis and some have potential as novel cancer and other disease biomarkers. This gene is one of the fifteen kallikrein subfamily members located in a cluster on chromosome 19. This protein is functionally conserved in its capacity to release the vasoactive peptide, Lys-bradykinin, from low molecular weight kininogen. [provided by RefSeq, Jul 2008],
组织表达
Isoform 2 is expressed in pancreas, salivary glands, kidney, colon, prostate gland, testis, spleen and the colon adenocarcinoma cell line T84.
细胞定位
nucleus,extracellular exosome,
功能
catalytic activity:Preferential cleavage of Arg-|-Xaa bonds in small molecule substrates. Highly selective action to release kallidin (lysyl-bradykinin) from kininogen involves hydrolysis of Met-|-Xaa or Leu-|-Xaa.,function:Glandular kallikreins cleave Met-Lys and Arg-Ser bonds in kininogen to release Lys-bradykinin.,online information:Kallikrein entry,PTM:The O-linked polysaccharides on Ser-93, Ser-104 and Ser-167 are probably the mucin type linked to GalNAc. In PubMed:3163150, GalNAc was detected with the corresponding peptides but not located.,similarity:Belongs to the peptidase S1 family.,similarity:Belongs to the peptidase S1 family. Kallikrein subfamily.,similarity:Contains 1 peptidase S1 domain.,tissue specificity:Isoform 2 is expressed in pancreas, salivary glands, kidney, colon, prostate gland, testis, spleen and the colon adenocarcinoma cell line T84.,
纯化
The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
