产品名称
MBOA7 Rabbit Polyclonal Antibody
基因名称
MBOAT7 BB1 LENG4 OACT7
存储缓冲液
Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% New type preservative N.
Human Gene Link
https://www.uniprot.org/uniprot/79143
Human Swissprot No.
Q96N66
Human Swissprot Link
https://www.uniprot.org/uniprotkb/Q96N66/entry
Mouse Gene Link
https://www.uniprot.org/uniprot/77582
Mouse Swissprot No.
Q8CHK3
Mouse Swissprot Link
https://www.uniprot.org/uniprotkb/Q8CHK3
免疫原
Synthesized peptide derived from human MBOA7 AA range: 293-343
特异性
This antibody detects endogenous levels of MBOA7 at Human/Mouse
宿主
Polyclonal, Rabbit,IgG
背景介绍
This gene encodes a member of the membrane-bound O-acyltransferases family of integral membrane proteins that have acyltransferase activity. The encoded protein is a lysophosphatidylinositol acyltransferase that has specificity for arachidonoyl-CoA as an acyl donor. This protein is involved in the reacylation of phospholipids as part of the phospholipid remodeling pathway known as the Land cycle. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Mar 2009],
组织表达
Overexpressed in metastatic breast and bladder carcinomas relative to normal breast epithelium and urothelium.
细胞定位
Endoplasmic reticulum membrane ; Multi-pass membrane protein . Localized in specific membrane structures termed mitochondria-associated membranes (MAMs) which connect the endoplasmic reticulum (ER) and the mitochondria. .
功能
catalytic activity:Acyl-CoA + 1-acyl-sn-glycero-3-phosphatidylinositol = CoA + 1,2-diacyl-sn-glycero-3-phosphatidylinositol.,enzyme regulation:Activity is inhibited by thimerosal.,function:Acyltransferase which mediates the conversion of lysophosphatidylinositol (1-acylglycerophosphatidylinositol or LPI) into phosphatidylinositol (1,2-diacyl-sn-glycero-3-phosphoinositol or PI) (LPIAT activity). Prefers arachidonoyl-CoA as the acyl donor. Lysophospholipid acyltransferases (LPLATs) catalyze the reacylation step of the phospholipid remodeling pathway also known as the Lands cycle.,pathway:Lipid metabolism; phospholipid metabolism.,similarity:Belongs to the membrane-bound acyltransferase family.,tissue specificity:Overexpressed in metastatic breast and bladder carcinomas relative to normal breast epithelium and urothelium.,
纯化
The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
