BD-PT5445

MAPK Organizer 1 Rabbit Polyclonal Antibody

WDR83; MORG1; WD repeat domain-containing protein 83; Mitogen-activated protein kinase organizer 1; MAPK organizer 1

常规抗体

WDR83

WD repeat domain-containing protein 83

WB

Human,Mouse,Rat

1 mg/ml

Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% New type preservative N.

84292

http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=84292

Q9BRX9

http://www.uniprot.org/uniprotkb/Q9BRX9/entry

67836

http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=67836

Q9DAJ4

http://www.uniprot.org/uniprot/Q9DAJ4

288924

http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=288924

Q5BLX8

http://www.uniprot.org/uniprot/Q5BLX8

The antiserum was produced against synthesized peptide derived from the Internal region of human WDR83. AA range:141-190

MAPK Organizer 1 Polyclonal Antibody detects endogenous levels of MAPK Organizer 1 protein.

WB 1:500 - 1:2000. IHC-p: 1:100-1:300. ELISA: 1:20000.. IF 1:50-200

34kD

-20°C/1 year

Polyclonal, Rabbit,IgG

This gene encodes a member of the WD-40 protein family. The protein is proposed to function as a molecular scaffold for various multimeric protein complexes. The protein associates with several components of the extracellular signal-regulated kinase (ERK) pathway, and promotes ERK activity in response to serum or other signals. The protein also interacts with egl nine homolog 3 (EGLN3, also known as PHD3) and regulates expression of hypoxia-inducible factor 1, and has been purified as part of the spliceosome. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Oct 2009],

Kidney proximal tubule,Muscle,

Cytoplasm . Nucleus . Predominantly cytoplasmic. Partially nuclear. .

function:Molecular scaffold protein for various multimeric protein complexes. Acts as a module in the assembly of a multicomponent scaffold for the ERK pathway, linking ERK responses to specific agonists. At low concentrations it enhances ERK activation, whereas high concentrations lead to the inhibition of ERK activation. Also involved in response to hypoxia by acting as a negative regulator of HIF1A/HIF-1-alpha via its interaction with EGLN3/PHD3. May promote degradation of HIF1A. May act by recruiting signaling complexes to a specific upstream activator (By similarity). May also be involved in pre-mRNA splicing.,similarity:Belongs to the WD repeat MORG1 family.,similarity:Contains 7 WD repeats.,subcellular location:Predominantly cytoplasmic (By similarity). Partially nuclear.,subunit:Interacts with EGLN3/PHD3. Interacts with ERK signaling proteins MAP2K1/MEK1, MAP2K2/MEK2, MAP2K1IP1/MP1, ARAF/Raf-1, MAPK1/ERK2 and MAPK3/ERK1 (By similarity). Identified in the spliceosome C complex, at least composed of AQR, ASCC3L1, C19orf29, CDC40, CDC5L, CRNKL1, DDX23, DDX41, DDX48, DDX5, DGCR14, DHX35, DHX38, DHX8, EFTUD2, FRG1, GPATC1, HNRPA1, HNRPA2B1, HNRPA3, HNRPC, HNRPF, HNRPH1, HNRPK, HNRPM, HNRPR, HNRPU, KIAA1160, KIAA1604, LSM2, LSM3, MAGOH, MORG1, PABPC1, PLRG1, PNN, PPIE, PPIL1, PPIL3, PPWD1, PRPF19, PRPF4B, PRPF6, PRPF8, RALY, RBM22, RBM8A, RBMX, SART1, SF3A1, SF3A2, SF3A3, SF3B1, SF3B2, SF3B3, SFRS1, SKIV2L2, SNRPA1, SNRPB, SNRPB2, SNRPD1, SNRPD2, SNRPD3, SNRPE, SNRPF, SNRPG, SNW1, SRRM1, SRRM2, SYF2, SYNCRIP, TFIP11, THOC4, U2AF1, WDR57, XAB2 and ZCCHC8.,

现货

The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.