产品名称
Eotaxin Rabbit Polyclonal Antibody
别名
CCL11; SCYA11; Eotaxin; C-C motif chemokine 11; Eosinophil chemotactic protein; Small-inducible cytokine A11
存储缓冲液
Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% New type preservative N.
Human Gene Link
http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=6356
Human Swissprot No.
P51671
Human Swissprot Link
http://www.uniprot.org/uniprotkb/P51671/entry
Mouse Gene Link
http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=20292
Mouse Swissprot No.
P48298
Mouse Swissprot Link
http://www.uniprot.org/uniprot/P48298
Rat Gene Link
http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=29397
Rat Swissprot Link
http://www.uniprot.org/uniprot/P97545
免疫原
The antiserum was produced against synthesized peptide derived from the Internal region of human CCL11. AA range:41-90
特异性
Eotaxin Polyclonal Antibody detects endogenous levels of Eotaxin protein.
稀释度
WB 1:500 - 1:2000. ELISA: 1:20000. Not yet tested in other applications.
宿主
Polyclonal, Rabbit,IgG
背景介绍
This antimicrobial gene is one of several chemokine genes clustered on the q-arm of chromosome 17. Chemokines form a superfamily of secreted proteins involved in immunoregulatory and inflammatory processes. The superfamily is divided into four subfamilies based on the arrangement of the N-terminal cysteine residues of the mature peptide. This chemokine, a member of the CC subfamily, displays chemotactic activity for eosinophils, but not mononuclear cells or neutrophils. This eosinophil-specific chemokine is thought to be involved in eosinophilic inflammatory diseases such as atopic dermatitis, allergic rhinitis, asthma and parasitic infections. [provided by RefSeq, Sep 2014],
组织表达
Blood,Foreskin,Lung,Placenta,Small intestine,
信号通路
Cytokine-cytokine receptor interaction;Chemokine;NOD-like receptor;Asthma;
功能
function:In response to the presence of allergens, this protein directly promotes the accumulation of eosinophils, a prominent feature of allergic inflammatory reactions. Binds to CCR3.,induction:By TNF-alpha, interleukin-1 alpha and interferon gamma.,online information:CCL11 entry,PTM:O-linked glycan consists of a Gal-GalNAc disaccharide which is mofified with up to 2 sialic acid residues.,similarity:Belongs to the intercrine beta (chemokine CC) family.,
纯化
The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.