产品名称
PGM1 Rabbit Polyclonal Antibody
别名
Phosphoglucomutase-1 (PGM 1) (EC 5.4.2.2) (Glucose phosphomutase 1)
存储缓冲液
Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.98% New type preservative N.
Human Gene Link
https://www.uniprot.org/uniprot/5236
Human Swissprot No.
P36871
Human Swissprot Link
https://www.uniprot.org/uniprotkb/P36871/entry
Mouse Gene Link
https://www.uniprot.org/uniprot/72157
Mouse Swissprot No.
Q9D0F9
Mouse Swissprot Link
https://www.uniprot.org/uniprotkb/Q9D0F9
Rat Swissprot Link
https://www.uniprot.org/uniprotkb/P38652
免疫原
Synthesized peptide derived from human PGM1 AA range: 318-368
特异性
This antibody detects endogenous levels of PGM1 at Human/Mouse/Rat
宿主
Polyclonal, Rabbit,IgG
背景介绍
The protein encoded by this gene is an isozyme of phosphoglucomutase (PGM) and belongs to the phosphohexose mutase family. There are several PGM isozymes, which are encoded by different genes and catalyze the transfer of phosphate between the 1 and 6 positions of glucose. In most cell types, this PGM isozyme is predominant, representing about 90% of total PGM activity. In red cells, PGM2 is a major isozyme. This gene is highly polymorphic. Mutations in this gene cause glycogen storage disease type 14. Alternativley spliced transcript variants encoding different isoforms have been identified in this gene.[provided by RefSeq, Mar 2010],
组织表达
Cervix,Epithelium,Hypothalamus,Placenta,Skeletal muscle,Skin,
细胞定位
[Isoform 1]: Cytoplasm.
功能
catalytic activity:Alpha-D-glucose 1-phosphate = alpha-D-glucose 6-phosphate.,cofactor:Binds 1 magnesium ion per subunit.,function:This enzyme participates in both the breakdown and synthesis of glucose.,polymorphism:Many polymorphic variants of PGM1 exist. 8 different alleles are known: PGM1*1+, PGM1*1-, PGM1*2+, PGM1*2-, PGM1*3+, PGM1*3-, PGM1*7+ and PGM1*7-. The sequence of PGM1*1+ is shown here.,similarity:Belongs to the phosphohexose mutase family.,subunit:Monomer.,
纯化
The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
