BD-PT5437

FGF-8 Rabbit Polyclonal Antibody

FGF8; AIGF; Fibroblast growth factor 8; FGF-8; Androgen-induced growth factor; AIGF; Heparin-binding growth factor 8; HBGF-8

常规抗体

FGF8

Fibroblast growth factor 8

WB

Human,Mouse,Rat

1 mg/ml

Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% New type preservative N.

2253

http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=2253

P55075

http://www.uniprot.org/uniprotkb/P55075/entry

14179

http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=14179

P37237

http://www.uniprot.org/uniprot/P37237

The antiserum was produced against synthesized peptide derived from the Internal region of human FGF8. AA range:141-190

FGF-8 Polyclonal Antibody detects endogenous levels of FGF-8 protein.

WB 1:500 - 1:2000. ELISA: 1:20000. Not yet tested in other applications.

26kD

-20°C/1 year

Polyclonal, Rabbit,IgG

The protein encoded by this gene is a member of the fibroblast growth factor (FGF) family. FGF family members possess broad mitogenic and cell survival activities, and are involved in a variety of biological processes, including embryonic development, cell growth, morphogenesis, tissue repair, tumor growth and invasion. This protein is known to be a factor that supports androgen and anchorage independent growth of mammary tumor cells. Overexpression of this gene has been shown to increase tumor growth and angiogensis. The adult expression of this gene is restricted to testes and ovaries. Temporal and spatial pattern of this gene expression suggests its function as an embryonic epithelial factor. Studies of the mouse and chick homologs revealed roles in midbrain and limb development, organogenesis, embryo gastrulation and left-right axis determination. The alternative splicing of this gene re

Oesophageal carcinoma,Placenta,Prostate,

Secreted.

MAPK_ERK_Growth;MAPK_G_Protein;Regulates Actin and Cytoskeleton;Pathways in cancer;Melanoma;

alternative products:Additional isoforms seem to exist,developmental stage:In adults expression is restricted to the gonads.,disease:Defects in FGF8 are a cause of idiopathic hypogonadotropic hypogonadism (IHH) [MIM:146110]. IHH is defined as a deficiency of the pituitary secretion of follicle-stimulating hormone and luteinizing hormone, which results in the impairment of pubertal maturation and of reproductive function.,disease:Defects in FGF8 are the cause of Kallmann syndrome type 6 (KAL6) [MIM:612702]. Kallmann syndrome is a disorder that associates hypogonadotropic hypogonadism and anosmia. Anosmia or hyposmia is related to the absence or hypoplasia of the olfactory bulbs and tracts. Hypogonadism is due to deficiency in gonadotropin-releasing hormone and probably results from a failure of embryonic migration of gonadotropin-releasing hormone-synthesizing neurons. In some patients other developmental anomalies can be present, which include renal agenesis, cleft lip and/or palate, selective tooth agenesis, and bimanual synkinesis. In some cases anosmia may be absent or inconspicuous.,function:Stimulates growth of the cells in an autocrine manner. Mediates hormonal action on the growth of cancer cells.,similarity:Belongs to the heparin-binding growth factors family.,

现货

The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.