产品名称
ECA39 Rabbit Polyclonal Antibody
别名
BCAT1; BCT1; ECA39; Branched-chain-amino-acid aminotransferase, cytosolic; BCAT(c); Protein ECA39
蛋白名称
Branched-chain-amino-acid aminotransferase, cytosolic
存储缓冲液
Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% New type preservative N.
Human Gene Link
http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=586
Human Swissprot No.
P54687
Human Swissprot Link
http://www.uniprot.org/uniprotkb/P54687/entry
Mouse Gene Link
http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=12035
Mouse Swissprot No.
P24288
Mouse Swissprot Link
http://www.uniprot.org/uniprot/P24288
Rat Gene Link
http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=29592
Rat Swissprot Link
http://www.uniprot.org/uniprot/P54690
免疫原
The antiserum was produced against synthesized peptide derived from the Internal region of human BCAT1. AA range:231-280
特异性
ECA39 Polyclonal Antibody detects endogenous levels of ECA39 protein.
宿主
Polyclonal, Rabbit,IgG
背景介绍
branched chain amino acid transaminase 1(BCAT1) Homo sapiens This gene encodes the cytosolic form of the enzyme branched-chain amino acid transaminase. This enzyme catalyzes the reversible transamination of branched-chain alpha-keto acids to branched-chain L-amino acids essential for cell growth. Two different clinical disorders have been attributed to a defect of branched-chain amino acid transamination: hypervalinemia and hyperleucine-isoleucinemia. As there is also a gene encoding a mitochondrial form of this enzyme, mutations in either gene may contribute to these disorders. Alternatively spliced transcript variants have been described. [provided by RefSeq, May 2010],
组织表达
During embryogenesis, expressed in the brain and kidney. Overexpressed in MYC-induced tumors such as Burkitt's lymphoma.
信号通路
Valine; leucine and isoleucine degradation;Valine; leucine and isoleucine biosynthesis;Pantothenate and CoA biosynthesis;
功能
catalytic activity:2-oxoglutaric acid + L-isoleucine = (S)-3-methyl-2-oxopentanoic acid + L-glutamic acid.,catalytic activity:2-oxoglutaric acid + L-valine = 3-methyl-2-oxobutanoic acid + L-glutamic acid.,catalytic activity:L-leucine + 2-oxoglutarate = 4-methyl-2-oxopentanoate + L-glutamate.,cofactor:Pyridoxal phosphate.,function:Catalyzes the first reaction in the catabolism of the essential branched chain amino acids leucine, isoleucine, and valine.,similarity:Belongs to the class-IV pyridoxal-phosphate-dependent aminotransferase family.,subunit:Homodimer.,tissue specificity:During embryogenesis, expressed in the brain and kidney. Overexpressed in C-myc induced tumors such as Burkitt's lymphoma.,
纯化
The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
