产品名称
DRA Rabbit Polyclonal Antibody
别名
SLC26A3; DRA; Chloride anion exchanger; Down-regulated in adenoma; Protein DRA; Solute carrier family 26 member 3
蛋白名称
Chloride anion exchanger
存储缓冲液
Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% New type preservative N.
Human Gene Link
http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=1811
Human Swissprot No.
P40879
Human Swissprot Link
http://www.uniprot.org/uniprotkb/P40879/entry
Mouse Gene Link
http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=13487
Mouse Swissprot No.
Q9WVC8
Mouse Swissprot Link
http://www.uniprot.org/uniprot/Q9WVC8
Rat Gene Link
http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=114629
Rat Swissprot Link
http://www.uniprot.org/uniprot/Q924C9
免疫原
Synthesized peptide derived from the C-terminal region of human DRA.
特异性
DRA Polyclonal Antibody detects endogenous levels of DRA protein.
稀释度
WB 1:500 - 1:2000. ELISA: 1:20000. Not yet tested in other applications.
宿主
Polyclonal, Rabbit,IgG
背景介绍
The protein encoded by this gene is a transmembrane glycoprotein that transports chloride ions across the cell membrane in exchange for bicarbonate ions. It is localized to the mucosa of the lower intestinal tract, particularly to the apical membrane of columnar epithelium and some goblet cells. The protein is essential for intestinal chloride absorption, and mutations in this gene have been associated with congenital chloride diarrhea. [provided by RefSeq, Oct 2008],
组织表达
Colon,Lung,Rectum tumor,
细胞定位
Apical cell membrane ; Multi-pass membrane protein . Membrane ; Multi-pass membrane protein . Localized in sperm membranes. Midpiece of sperm tail. Colocalizes with CFTR at the midpiece of sperm tail (By similarity). .
功能
developmental stage:Expression is significantly decreased in adenomas (polyps) and adenocarcinomas of the colon.,disease:Defects in SLC26A3 are the cause of congenital chloride diarrhea (CLD) [MIM:214700]. CLD is a disease characterized by voluminous watery stools containing an excess of chloride. The children with this disease are often premature.,function:Chloride/bicarbonate exchanger. Involved in absorbtion of in the colon. Helps mediate electrolyte and fluid absorption.,PTM:Phosphorylated upon DNA damage, probably by ATM or ATR.,similarity:Belongs to the SLC26A/SulP transporter (TC 2.A.53) family.,similarity:Contains 1 STAS domain.,subunit:Interacts with PDZK1.,
纯化
The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
