BD-PT5416

IDH1 Rabbit Polyclonal Antibody

IDH1; PICD; Isocitrate dehydrogenase [NADP] cytoplasmic; IDH; Cytosolic NADP-isocitrate dehydrogenase; IDP; NADP(+)-specific ICDH; Oxalosuccinate decarboxylase

常规抗体

IDH1

Isocitrate dehydrogenase [NADP] cytoplasmic

WB

Human,Mouse,Rat

1 mg/ml

Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% New type preservative N.

3417

http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=3417

O75874

http://www.uniprot.org/uniprotkb/O75874/entry

15926

http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=15926

O88844

http://www.uniprot.org/uniprot/O88844

24479

http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=24479

P41562

http://www.uniprot.org/uniprot/P41562

Synthesized peptide derived from the N-terminal region of human IDH1.

IDH1 Polyclonal Antibody detects endogenous levels of IDH1 protein.

WB 1:500 - 1:2000. IHC-p: 1:100-1:300. ELISA: 1:20000.. IF 1:50-200

46kD

-20°C/1 year

Polyclonal, Rabbit,IgG

Isocitrate dehydrogenases catalyze the oxidative decarboxylation of isocitrate to 2-oxoglutarate. These enzymes belong to two distinct subclasses, one of which utilizes NAD(+) as the electron acceptor and the other NADP(+). Five isocitrate dehydrogenases have been reported: three NAD(+)-dependent isocitrate dehydrogenases, which localize to the mitochondrial matrix, and two NADP(+)-dependent isocitrate dehydrogenases, one of which is mitochondrial and the other predominantly cytosolic. Each NADP(+)-dependent isozyme is a homodimer. The protein encoded by this gene is the NADP(+)-dependent isocitrate dehydrogenase found in the cytoplasm and peroxisomes. It contains the PTS-1 peroxisomal targeting signal sequence. The presence of this enzyme in peroxisomes suggests roles in the regeneration of NADPH for intraperoxisomal reductions, such as the conversion of 2, 4-dienoyl-CoAs to

Brain,Cajal-Retzius cell,Fetal brain cortex,Human endometri

Cytoplasm, cytosol . Peroxisome .

Citrate cycle (TCA cycle);Glutathione metabolism;

catalytic activity:Isocitrate + NADP(+) = 2-oxoglutarate + CO(2) + NADPH.,catalytic activity:Oxalosuccinate + NADP(+) = 2-oxoglutarate + CO(2) + NADPH.,cofactor:Binds 1 magnesium or manganese ion per subunit.,disease:Defects in IDH1 are a cause of glioblastoma multiforme (GBM) [MIM:137800]; also called familial glioma of brain. Gliomas are central nervous system neoplasms derived from glial cells and comprise astrocytomas, glioblastoma multiforme, oligodendrogliomas, and ependymomas.,miscellaneous:Cancer mutations affecting Arg-132 are tissue-specific, and suggest that this residue plays a unique role in the development of high-grade gliomas.,online information:Isocitrate dehydrogenase entry,similarity:Belongs to the isocitrate and isopropylmalate dehydrogenases family.,subunit:Homodimer.,

现货

The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.