BD-PT5414

PD-ECGF Rabbit Polyclonal Antibody

TYMP; ECGF1; Thymidine phosphorylase; TP; Gliostatin; Platelet-derived endothelial cell growth factor; PD-ECGF; TdRPase

常规抗体

TYMP

Thymidine phosphorylase

WB

Human,Rat,Mouse

1 mg/ml

Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% New type preservative N.

1890

http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=1890

P19971

http://www.uniprot.org/uniprotkb/P19971/entry

72962

http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=72962

Q99N42

http://www.uniprot.org/uniprot/Q99N42

315219

http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=315219

Q5FVR2

http://www.uniprot.org/uniprot/Q5FVR2

The antiserum was produced against synthesized peptide derived from the N-terminal region of human TYMP. AA range:11-60

PD-ECGF Polyclonal Antibody detects endogenous levels of PD-ECGF protein.

WB 1:500 - 1:2000. IHC-p: 1:100-1:300. ELISA: 1:20000.. IF 1:50-200

50kD

-20°C/1 year

Polyclonal, Rabbit,IgG

This gene encodes an angiogenic factor which promotes angiogenesis in vivo and stimulates the in vitro growth of a variety of endothelial cells. It has a highly restricted target cell specificity acting only on endothelial cells. Mutations in this gene have been associated with mitochondrial neurogastrointestinal encephalomyopathy. Multiple alternatively spliced transcript variants have been identified. [provided by RefSeq, Apr 2012],

Brain,Lung,Placenta,Synovial membrane tissue,

cytosol,

Pyrimidine metabolism;Drug metabolism;Bladder cancer;

catalytic activity:Thymidine + phosphate = thymine + 2-deoxy-alpha-D-ribose 1-phosphate.,disease:Defects in TYMP are the cause of mitochondrial neurogastrointestinal encephalomyopathy (MNGIE) [MIM:603041]; also known as myoneurogastrointestinal encephalomyopathy. MNGIE is an autosomal recessive disease associated with multiple deletions of skeletal muscle mitochondrial DNA (MtDNA). It is clinically characterized by onset between the second and fifth decades of life, ptosis, progressive external ophthalmoplegia, gastrointestinal dysmotility (often pseudoobstruction), diffuse leukoencephalopathy, thin body habitus, peripheral neuropathy, and myopathy.,function:Catalyzes the reversible phosphorolysis of thymidine. The produced molecules are then utilized as carbon and energy sources or in the rescue of pyrimidine bases for nucleotide synthesis.,function:May have a role in maintaining the integrity of the blood vessels. Has growth promoting activity on endothelial cells, angiogenic activity in vivo and chemotactic activity on endothelial cells in vitro.,pathway:Pyrimidine metabolism; dTMP biosynthesis via salvage pathway; dTMP from thymine: step 1/2.,similarity:Belongs to the thymidine/pyrimidine-nucleoside phosphorylase family.,subunit:Homodimer.,

现货

The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.