产品名称
Nov Rabbit Polyclonal Antibody
别名
NOV; CCN3; IGFBP9; NOVH; Protein NOV homolog; NovH; CCN family member 3; Insulin-like growth factor-binding protein 9; IBP-9; IGF-binding protein 9; IGFBP-9; Nephroblastoma-overexpressed gene protein homolog
存储缓冲液
Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% New type preservative N.
Human Gene Link
http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=4856
Human Swissprot No.
P48745
Human Swissprot Link
http://www.uniprot.org/uniprotkb/P48745/entry
Mouse Gene Link
http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=18133
Mouse Swissprot No.
Q64299
Mouse Swissprot Link
http://www.uniprot.org/uniprot/Q64299
Rat Gene Link
http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=81526
Rat Swissprot Link
http://www.uniprot.org/uniprot/Q9QZQ5
免疫原
The antiserum was produced against synthesized peptide derived from the Internal region of human NOV. AA range:221-270
特异性
Nov Polyclonal Antibody detects endogenous levels of Nov protein.
稀释度
WB 1:500 - 1:2000. IHC-p: 1:100-1:300. ELISA: 1:20000.. IF 1:50-200
宿主
Polyclonal, Rabbit,IgG
背景介绍
The protein encoded by this gene is a small secreted cysteine-rich protein and a member of the CCN family of regulatory proteins. CNN family proteins associate with the extracellular matrix and play an important role in cardiovascular and skeletal development, fibrosis and cancer development. [provided by RefSeq, Feb 2009],
组织表达
Expressed in endiothelial cells (at protein level) (PubMed:21063504). Expressed in bone marrow, thymic cells and nephroblastoma. Increased expression in Wilms tumor of the stromal type.
细胞定位
Secreted. Cytoplasm . Cell junction, gap junction . Localizes at the gap junction in presence of GJA1. .
功能
function:Immediate-early protein likely to play a role in cell growth regulation.,similarity:Belongs to the CCN family.,similarity:Contains 1 CTCK (C-terminal cystine knot-like) domain.,similarity:Contains 1 IGFBP N-terminal domain.,similarity:Contains 1 TSP type-1 domain.,similarity:Contains 1 VWFC domain.,subunit:Interacts with FBLN1.,tissue specificity:Increased expression in Wilms tumor of the stromal type.,
纯化
The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
