产品名称
MDA-7 Rabbit Polyclonal Antibody
别名
IL24; MDA7; ST16; Interleukin-24; IL-24; Melanoma differentiation-associated gene 7 protein; MDA-7; Suppression of tumorigenicity 16 protein
存储缓冲液
Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% New type preservative N.
Human Gene Link
http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=11009
Human Swissprot No.
Q13007
Human Swissprot Link
http://www.uniprot.org/uniprotkb/Q13007/entry
Mouse Gene Link
http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=93672
Mouse Swissprot No.
Q925S4
Mouse Swissprot Link
http://www.uniprot.org/uniprot/Q925S4
Rat Gene Link
http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=170819
Rat Swissprot Link
http://www.uniprot.org/uniprot/Q9JI24
免疫原
The antiserum was produced against synthesized peptide derived from the Internal region of human IL24. AA range:131-180
特异性
MDA-7 Polyclonal Antibody detects endogenous levels of MDA-7 protein.
稀释度
WB 1:500 - 1:2000. IHC-p: 1:100-1:300. ELISA: 1:20000.. IF 1:50-200
宿主
Polyclonal, Rabbit,IgG
背景介绍
This gene encodes a member of the IL10 family of cytokines. It was identified as a gene induced during terminal differentiation in melanoma cells. The protein encoded by this gene can induce apoptosis selectively in various cancer cells. Overexpression of this gene leads to elevated expression of several GADD family genes, which correlates with the induction of apoptosis. The phosphorylation of mitogen-activated protein kinase 14 (MAPK7/P38), and heat shock 27kDa protein 1 (HSPB2/HSP27) are found to be induced by this gene in melanoma cells, but not in normal immortal melanocytes. Alternatively spliced transcript variants encoding distinct isoforms have been reported. [provided by RefSeq, Jul 2008],
组织表达
Up-regulated in melanoma cells induced to terminally differentiate.
信号通路
Cytokine-cytokine receptor interaction;Jak_STAT;
功能
caution:The sequence shown here is derived from an Ensembl automatic analysis pipeline and should be considered as preliminary data.,function:Has antiproliferative properties on melanoma cells and may contribute to terminal cell differentiation.,online information:Interleukin-24 entry,similarity:Belongs to the IL-10 family.,tissue specificity:Up-regulated in melanoma cells induced to terminally differentiate.,
纯化
The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
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