产品名称
Cerberus Rabbit Polyclonal Antibody
别名
CER1; DAND4; Cerberus; Cerberus-related protein; DAN domain family member 4
存储缓冲液
Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% New type preservative N.
Human Gene Link
http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=9350
Human Swissprot No.
O95813
Human Swissprot Link
http://www.uniprot.org/uniprotkb/O95813/entry
Mouse Gene Link
http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=12622
Mouse Swissprot No.
O55233
Mouse Swissprot Link
http://www.uniprot.org/uniprot/O55233
免疫原
The antiserum was produced against synthesized peptide derived from the Internal region of human CER1. AA range:91-140
特异性
Cerberus Polyclonal Antibody detects endogenous levels of Cerberus protein.
稀释度
WB 1:500 - 1:2000. IHC-p: 1:100-1:300. ELISA: 1:20000.. IF 1:50-200
宿主
Polyclonal, Rabbit,IgG
背景介绍
This gene encodes a cytokine member of the cysteine knot superfamily, characterized by nine conserved cysteines and a cysteine knot region. The cerberus-related cytokines, together with Dan and DRM/Gremlin, represent a group of bone morphogenetic protein (BMP) antagonists that can bind directly to BMPs and inhibit their activity. [provided by RefSeq, Jul 2008],
组织表达
Blood,PCR rescued clones,
功能
function:Cytokine that may play a role in anterior neural induction and somite formation during embryogenesis in part through a BMP-inhibitory mechanism. Can regulate Nodal signaling during gastrulation as well as the formation and patterning of the primitive streak.,PTM:N-glycosylated.,sequence caution:Translated as Ser.,similarity:Belongs to the DAN family.,similarity:Contains 1 CTCK (C-terminal cystine knot-like) domain.,subunit:Forms monomers and predominantly dimers.,
纯化
The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
