产品名称
DNAM-1 Rabbit Polyclonal Antibody
别名
CD226; DNAM1; CD226 antigen; DNAX accessory molecule 1; DNAM-1; CD226
存储缓冲液
Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% New type preservative N.
Human Gene Link
http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=10666
Human Swissprot No.
Q15762
Human Swissprot Link
http://www.uniprot.org/uniprotkb/Q15762/entry
Mouse Gene Link
http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=225825
Mouse Swissprot No.
Q8K4F0
Mouse Swissprot Link
http://www.uniprot.org/uniprot/Q8K4F0
免疫原
The antiserum was produced against synthesized peptide derived from the Internal region of human CD226. AA range:71-120
特异性
DNAM-1 Polyclonal Antibody detects endogenous levels of DNAM-1 protein.
稀释度
WB 1:500 - 1:2000. ELISA: 1:20000. Not yet tested in other applications.
宿主
Polyclonal, Rabbit,IgG
背景介绍
This gene encodes a glycoprotein expressed on the surface of NK cells, platelets, monocytes and a subset of T cells. It is a member of the Ig-superfamily containing 2 Ig-like domains of the V-set. The protein mediates cellular adhesion of platelets and megakaryocytic cells to vascular endothelial cells. The protein also plays a role in megakaryocytic cell maturation. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Jan 2015],
组织表达
Expressed by peripheral blood T-lymphocytes.
细胞定位
Cell membrane ; Single-pass type I membrane protein .
信号通路
Cell adhesion molecules (CAMs);
功能
function:Receptor involved in intercellular adhesion, lymphocyte signaling, cytotoxicity and lymphokine secretion mediated by cytotoxic T-lymphocyte (CTL) and NK cell.,PTM:Phosphorylated.,similarity:Contains 2 Ig-like C2-type (immunoglobulin-like) domains.,subunit:Interacts with PVR and PVRL2.,tissue specificity:Expressed by peripheral blood T-lymphocytes.,
纯化
The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
