BD-PT5397

IL-8Rβ Rabbit Polyclonal Antibody

CXCR2; IL8RB; C-X-C chemokine receptor type 2; CXC-R2; CXCR-2; CDw128b; GRO/MGSA receptor; High affinity interleukin-8 receptor B; IL-8R B; IL-8 receptor type 2; CD182

常规抗体

CXCR2

C-X-C chemokine receptor type 2

WB

Human,Rat,Mouse

1 mg/ml

Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% New type preservative N.

3579

http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=3579

P25025

http://www.uniprot.org/uniprotkb/P25025/entry

P35343

http://www.uniprot.org/uniprot/P35343

The antiserum was produced against synthesized peptide derived from the N-terminal region of human CXCR2. AA range:1-50

IL-8Rβ Polyclonal Antibody detects endogenous levels of IL-8Rβ protein.

WB 1:500 - 1:2000. IHC-p: 1:100-1:300. ELISA: 1:20000.. IF 1:50-200

40kD

-20°C/1 year

Polyclonal, Rabbit,IgG

C-X-C motif chemokine receptor 2(CXCR2) Homo sapiens The protein encoded by this gene is a member of the G-protein-coupled receptor family. This protein is a receptor for interleukin 8 (IL8). It binds to IL8 with high affinity, and transduces the signal through a G-protein activated second messenger system. This receptor also binds to chemokine (C-X-C motif) ligand 1 (CXCL1/MGSA), a protein with melanoma growth stimulating activity, and has been shown to be a major component required for serum-dependent melanoma cell growth. This receptor mediates neutrophil migration to sites of inflammation. The angiogenic effects of IL8 in intestinal microvascular endothelial cells are found to be mediated by this receptor. Knockout studies in mice suggested that this receptor controls the positioning of oligodendrocyte precursors in developing spinal cord by arresting their migration. This gene, IL8RA, a gene encoding another high affinity IL8 receptor, as

Brain,Placenta,

Cell membrane; Multi-pass membrane protein.

Cytokine-cytokine receptor interaction;Chemokine;Endocytosis;Epithelial cell signaling in Helicobacter pylori infection;

function:Receptor for interleukin-8 which is a powerful neutrophil chemotactic factor. Binding of IL-8 to the receptor causes activation of neutrophils. This response is mediated via a G-protein that activates a phosphatidylinositol-calcium second messenger system. Binds to IL-8 with high affinity. Also binds with high affinity to CXCL3, GRO/MGSA and NAP-2.,online information:CXC chemokine receptors entry,PTM:Phosphorylated upon ligand binding; which is required for desensitization.,similarity:Belongs to the G-protein coupled receptor 1 family.,

现货

The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.