产品名称
CD38 Rabbit Polyclonal Antibody
别名
CD38; ADP-ribosyl cyclase 1; Cyclic ADP-ribose hydrolase 1; cADPr hydrolase 1; T10; CD38
蛋白名称
ADP-ribosyl cyclase 1
存储缓冲液
Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% New type preservative N.
Human Gene Link
http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=952
Human Swissprot No.
P28907
Human Swissprot Link
http://www.uniprot.org/uniprotkb/P28907/entry
Mouse Swissprot No.
P56528
Mouse Swissprot Link
http://www.uniprot.org/uniprot/P56528
免疫原
The antiserum was produced against synthesized peptide derived from the Internal region of human CD38. AA range:211-260
特异性
CD38 Polyclonal Antibody detects endogenous levels of CD38 protein.
稀释度
WB 1:500 - 1:2000. IHC-p: 1:100-1:300. ELISA: 1:20000.. IF 1:50-200
宿主
Polyclonal, Rabbit,IgG
背景介绍
The protein encoded by this gene is a non-lineage-restricted, type II transmembrane glycoprotein that synthesizes and hydrolyzes cyclic adenosine 5'-diphosphate-ribose, an intracellular calcium ion mobilizing messenger. The release of soluble protein and the ability of membrane-bound protein to become internalized indicate both extracellular and intracellular functions for the protein. This protein has an N-terminal cytoplasmic tail, a single membrane-spanning domain, and a C-terminal extracellular region with four N-glycosylation sites. Crystal structure analysis demonstrates that the functional molecule is a dimer, with the central portion containing the catalytic site. It is used as a prognostic marker for patients with chronic lymphocytic leukemia. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Sep 2015],
组织表达
Expressed at high levels in pancreas, liver, kidney, brain, testis, ovary, placenta, malignant lymphoma and neuroblastoma.
细胞定位
Membrane; Single-pass type II membrane protein.
信号通路
Nicotinate and nicotinamide metabolism;Calcium;Hematopoietic cell lineage;
功能
catalytic activity:NAD(+) + H(2)O = ADP-ribose + nicotinamide.,developmental stage:Preferentially expressed at both early and late stages of the B and T-cell maturation. It is also detected on erythroid and myeloid progenitors in bone marrow, where the level of surface expression was shown to decrease during differentiation of blast-forming unit E to colony-forming unit E.,enzyme regulation:ATP inhibits the hydrolyzing activity.,function:Synthesizes cyclic ADP-ribose, a second messenger for glucose-induced insulin secretion. Also has cADPr hydrolase activity. Also moonlights as a receptor in cells of the immune system.,online information:CD38 entry,similarity:Belongs to the ADP-ribosyl cyclase family.,tissue specificity:Expressed at high levels in pancreas, liver, kidney, brain, testis, ovary, placenta, malignant lymphoma and neuroblastoma.,
纯化
The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
