BD-PT5390

VDAC1 Rabbit Polyclonal Antibody

VDAC1; VDAC; Voltage-dependent anion-selective channel protein 1; VDAC-1; hVDAC1; Outer mitochondrial membrane protein porin 1; Plasmalemmal porin; Porin 31HL; Porin 31HM

常规抗体

VDAC1

Voltage-dependent anion-selective channel protein 1

WB

Human,Mouse,Rat

1 mg/ml

Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% New type preservative N.

7416

http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=7416

P21796

http://www.uniprot.org/uniprotkb/P21796/entry

22333

http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=22333

Q60932

http://www.uniprot.org/uniprot/Q60932

83529

http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=83529

Q9Z2L0

http://www.uniprot.org/uniprot/Q9Z2L0

The antiserum was produced against synthesized peptide derived from the N-terminal region of human VDAC1. AA range:1-50

VDAC1 Polyclonal Antibody detects endogenous levels of VDAC1 protein.

WB 1:500 - 1:2000. ELISA: 1:20000. Not yet tested in other applications.

31kD

-20°C/1 year

Polyclonal, Rabbit,IgG

This gene encodes a voltage-dependent anion channel protein that is a major component of the outer mitochondrial membrane. The encoded protein facilitates the exchange of metabolites and ions across the outer mitochondrial membrane and may regulate mitochondrial functions. This protein also forms channels in the plasma membrane and may be involved in transmembrane electron transport. Alternate splicing results in multiple transcript variants. Multiple pseudogenes of this gene are found on chromosomes 1, 2 3, 6, 9, 12, X and Y.[provided by RefSeq, Sep 2010],

Expressed in erythrocytes (at protein level) (PubMed:27641616). Expressed in heart, liver and skeletal muscle (PubMed:8420959).

Mitochondrion outer membrane ; Multi-pass membrane protein . Cell membrane ; Multi-pass membrane protein . Membrane raft ; Multi-pass membrane protein .

Calcium;Parkinson's disease;Huntington's disease;

domain:Consists mainly of a membrane-spanning beta-barrel formed by 19 beta-strands. The helical N-terminus folds back into the pore opening and plays a role in voltage-gated channel activity.,function:Forms a channel through the mitochondrial outer membrane and also the plasma membrane. The channel at the outer mitochondrial membrane allows diffusion of small hydrophilic molecules; in the plasma membrane it is involved in cell volume regulation and apoptosis. It adopts an open conformation at low or zero membrane potential and a closed conformation at potentials above 30-40 mV. The open state has a weak anion selectivity whereas the closed state is cation-selective. May participate in the formation of the permeability transition pore complex (PTPC) responsible for the release of mitochondrial products that triggers apoptosis.,similarity:Belongs to the eukaryotic mitochondrial porin family.,subunit:Interacts with hexokinases (By similarity). Interacts with BCL2L1. Interacts with influenza A virus PB1-F2 protein.,tissue specificity:Heart, liver and skeletal muscle.,

现货

The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.