BD-PT5389

CacyBP Rabbit Polyclonal Antibody

CACYBP; S100A6BP; SIP; PNAS-107; Calcyclin-binding protein; CacyBP; hCacyBP; S100A6-binding protein; Siah-interacting protein

常规抗体

CACYBP

Calcyclin-binding protein

WB

Human,Mouse,Rat

1 mg/ml

Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% New type preservative N.

27101

http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=27101

Q9HB71

http://www.uniprot.org/uniprotkb/Q9HB71/entry

12301

http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=12301

Q9CXW3

http://www.uniprot.org/uniprot/Q9CXW3

289144

http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=289144

Q6AYK6

http://www.uniprot.org/uniprot/Q6AYK6

The antiserum was produced against synthesized peptide derived from the C-terminal region of human CACYBP. AA range:171-220

CacyBP Polyclonal Antibody detects endogenous levels of CacyBP protein.

WB 1:500 - 1:2000. IHC-p: 1:100-1:300. ELISA: 1:20000.. IF 1:50-200

25kD

-20°C/1 year

Polyclonal, Rabbit,IgG

The protein encoded by this gene is a calcyclin binding protein. It may be involved in calcium-dependent ubiquitination and subsequent proteosomal degradation of target proteins. It probably serves as a molecular bridge in ubiquitin E3 complexes and participates in the ubiquitin-mediated degradation of beta-catenin. Two alternatively spliced transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jul 2008],

Brain,Colon carcinoma,Hepatoma,Liver,Promyelocytic leukemia,Skeletal muscle

Nucleus . Cytoplasm . Cytoplasmic at low calcium concentrations. In neuroblastoma cells, after a retinoic acid (RA) induction and calcium increase, it localizes in both the nucleus and cytoplasm. The nuclear fraction may be phosphorylated.

WNT;WNT-T CELL

function:May be involved in calcium-dependent ubiquitination and subsequent proteosomal degradation of target proteins. Probably serves as a molecular bridge in ubiquitin E3 complexes. Participates in the ubiquitin-mediated degradation of beta-catenin (CTNNB1).,PTM:Phosphorylated on serine residues. Phosphorylated upon induction by RA or at high calcium concentrations.,similarity:Contains 1 CS domain.,similarity:Contains 1 SGS domain.,subcellular location:Cytoplasmic at low calcium concentrations. In neuroblastoma cells, after a retinoic acid (RA) induction and calcium increase, it localizes in both the nucleus and cytoplasm. The nuclear fraction may be phosphorylated.,subunit:Interacts with protein of the S100 family S100A1, S100A6, S100B, S100P and S100A12 at physiological calcium concentrations (By similarity). Component of some large E3 complex at least composed of UBE2D1, SIAH1, CACYBP/SIP, SKP1, APC and TBL1X. Interacts directly with SIAH1, SIAH2 and SKP1.,

现货

The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.