产品名称
Connexin-40 Rabbit Polyclonal Antibody
别名
GJA5; Gap junction alpha-5 protein; Connexin-40; Cx40
蛋白名称
Gap junction alpha-5 protein
存储缓冲液
Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% New type preservative N.
Human Gene Link
http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=2702
Human Swissprot No.
P36382
Human Swissprot Link
http://www.uniprot.org/uniprotkb/P36382/entry
Mouse Gene Link
http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=14613
Mouse Swissprot No.
Q01231
Mouse Swissprot Link
http://www.uniprot.org/uniprot/Q01231
Rat Gene Link
http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=50563
Rat Swissprot Link
http://www.uniprot.org/uniprot/P28234
免疫原
The antiserum was produced against synthesized peptide derived from the N-terminal region of human GJA5. AA range:21-70
特异性
Connexin-40 Polyclonal Antibody detects endogenous levels of Connexin-40 protein.
稀释度
WB 1:500 - 1:2000. ELISA: 1:20000. Not yet tested in other applications.
宿主
Polyclonal, Rabbit,IgG
背景介绍
This gene is a member of the connexin gene family. The encoded protein is a component of gap junctions, which are composed of arrays of intercellular channels that provide a route for the diffusion of low molecular weight materials from cell to cell. Mutations in this gene may be associated with atrial fibrillation. Alternatively spliced transcript variants encoding the same isoform have been described. [provided by RefSeq, Jul 2008],
细胞定位
Cell membrane; Multi-pass membrane protein. Cell junction, gap junction.
功能
disease:Defects in GJA5 are a cause of idiopathic atrial fibrillation [MIM:108770]. Atrial fibrillation (AF) is the most common cardiac arrhythmia and is characterized by rapid and irregular activation of the atrium.,function:One gap junction consists of a cluster of closely packed pairs of transmembrane channels, the connexons, through which materials of low MW diffuse from one cell to a neighboring cell.,similarity:Belongs to the connexin family. Alpha-type (group II) subfamily.,subunit:A connexon is composed of a hexamer of connexins.,
纯化
The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
