产品名称
SCYL1BP1 Rabbit Polyclonal Antibody
别名
GORAB; NTKLBP1; SCYL1BP1; RAB6-interacting golgin; N-terminal kinase-like-binding protein 1; NTKL-BP1; NTKL-binding protein 1; hNTKL-BP1; SCY1-like 1-binding protein 1; SCYL1-BP1; SCYL1-binding protein 1
蛋白名称
RAB6-interacting golgin
存储缓冲液
Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% New type preservative N.
Human Gene Link
http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=92344
Human Swissprot No.
Q5T7V8
Human Swissprot Link
http://www.uniprot.org/uniprotkb/Q5T7V8/entry
Mouse Gene Link
http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=98376
Mouse Swissprot No.
Q8BRM2
Mouse Swissprot Link
http://www.uniprot.org/uniprot/Q8BRM2
Rat Gene Link
http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=304923
Rat Swissprot Link
http://www.uniprot.org/uniprot/B1H222
免疫原
The antiserum was produced against synthesized peptide derived from the N-terminal region of human GORAB. AA range:1-50
特异性
SCYL1BP1 Polyclonal Antibody detects endogenous levels of SCYL1BP1 protein.
稀释度
WB 1:500-2000;IHC-p 1:50-300; ELISA 2000-20000
宿主
Polyclonal, Rabbit,IgG
背景介绍
golgin, RAB6 interacting(GORAB) Homo sapiens This gene encodes a member of the golgin family, a group of coiled-coil proteins localized to the Golgi. The encoded protein may function in the secretory pathway. The encoded protein, which also localizes to the cytoplasm, was identified by interactions with the N-terminal kinase-like protein, and thus it may function in mitosis. Mutations in this gene have been associated with geroderma osteodysplastica. Alternatively spliced transcript variants have been described. [provided by RefSeq, Mar 2009],
组织表达
Embryo,Pancreas,Testis,Trachea,
细胞定位
Cytoplasm . Golgi apparatus .
功能
caution:It is uncertain whether Met-1 or Met-26 is the initiator.,disease:Defects in GORAB are the cause of geroderma osteodysplasticum (GO) [MIM:231070]; also known as gerodermia osteodysplastica or Walt Disney dwarfism. GO is a rare autosomal recessive disorder characterized by lax, wrinkled skin, joint laxity and a typical face with a prematurely aged appearance. Skeletal signs include severe osteoporosis leading to frequent fractures, malar and mandibular hypoplasia and a variable degree of growth retardation.,similarity:Belongs to the GORAB family.,subunit:Interacts with SCYL1 (By similarity). Interacts with RCHY1 and RAB6A/RAB6.,
纯化
The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
