产品名称
S2610 Rabbit Polyclonal Antibody
别名
Solute carrier family 26 member 10
存储缓冲液
Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.111% New type preservative N.
Human Gene Link
https://www.uniprot.org/uniprot/65012
Human Swissprot No.
Q8NG04
Human Swissprot Link
https://www.uniprot.org/uniprotkb/Q8NG04/entry
Mouse Gene Link
https://www.uniprot.org/uniprot/0
Mouse Swissprot No.
Q5EBI0
Mouse Swissprot Link
https://www.uniprot.org/uniprotkb/Q5EBI0
免疫原
Synthesized peptide derived from human S2610 AA range: 295-345
特异性
This antibody detects endogenous levels of S2610 at Human/Mouse
宿主
Polyclonal, Rabbit,IgG
组织表达
Brain,Cerebellum,Testis,
细胞定位
Membrane ; Multi-pass membrane protein .
功能
caution:According to PubMed:12759755, it is a transcribed pseudogene. They however do not provide experimental evidences to support this affirmation.,domain:The guanine nucleotide exchange activity is autoinhibited by the PH domain.,function:Chloride/bicarbonate exchanger.,function:May play a role in actin cytoskeleton reorganization in different tissues since its activation induces formation of actin stress fibers. It works as a guanine nucleotide exchange factor for Rho family of small GTPases. Links specifically G alpha q/11-coupled receptors to RHOA activation. May be an important regulator of processes involved in axon and dendrite formation. In neurons seems to be an exchange factor primarily for RAC1. Involved in skeletal myogenesis.,similarity:Belongs to the SLC26A/SulP transporter (TC 2.A.53) family.,similarity:Contains 1 DH (DBL-homology) domain.,similarity:Contains 1 PH domain.,similarity:Contains 1 STAS domain.,subcellular location:Highly colocalizes with actin regions.,subunit:Interacts with activated GNAQ and GNA11. Interacts with RHOA, CDC42 and RAC1.,tissue specificity:Isoforms 1 and 2 are highly expressed in excitable tissues, such as brain, heart and muscle. Also detected in kidney and liver.,
纯化
The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
