产品名称
EMD Rabbit Polyclonal Antibody
存储缓冲液
Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% New type preservative N.
Human Gene Link
https://www.uniprot.org/uniprot/2010
Human Swissprot No.
P50402
Human Swissprot Link
https://www.uniprot.org/uniprotkb/P50402/entry
Mouse Gene Link
https://www.uniprot.org/uniprot/13726
Mouse Swissprot No.
O08579
Mouse Swissprot Link
https://www.uniprot.org/uniprotkb/O08579
Rat Gene Link
https://www.uniprot.org/uniprot/25437
Rat Swissprot Link
https://www.uniprot.org/uniprotkb/Q63190
免疫原
Synthesized peptide derived from human EMD AA range: 151-201
特异性
This antibody detects endogenous levels of EMD at Human/Mouse/Rat
宿主
Polyclonal, Rabbit,IgG
背景介绍
Emerin is a serine-rich nuclear membrane protein and a member of the nuclear lamina-associated protein family. It mediates membrane anchorage to the cytoskeleton. Dreifuss-Emery muscular dystrophy is an X-linked inherited degenerative myopathy resulting from mutation in the emerin gene. [provided by RefSeq, Jul 2008],
组织表达
Skeletal muscle, heart, colon, testis, ovary and pancreas.
细胞定位
Nucleus inner membrane ; Single-pass membrane protein; Nucleoplasmic side . Nucleus outer membrane. Colocalized with BANF1 at the central region of the assembling nuclear rim, near spindle-attachment sites. The accumulation of different intermediates of prelamin-A/C (non-farnesylated or carboxymethylated farnesylated prelamin-A/C) in fibroblasts modify its localization in the nucleus.
功能
disease:Defects in EMD are a cause of X-linked Emery-Dreifuss muscular dystrophy (X-EDMD) [MIM:310300]. X-EDMD is an X-linked disorder characterized by early contractures, muscle wasting and weakness and cardiomyopathy.,miscellaneous:Binding to BCLAF1 is specifically and selectively disrupted by the disease-associated Phe-54 missense mutation.,online information:"EMD mutation database",PTM:Found in four different phosphorylated forms, three of which appear to be associated with the cell cycle.,similarity:Contains 1 LEM domain.,subcellular location:Colocalized with BANF1 at the central region of the assembling nuclear rim, near spindle-attachment sites.,subunit:Interacts with lamins A and C, BANF1, GMCL, BCLAF1 and YTHDC1/YT521. Interacts with TMEM43; the interaction retains emerin in the nuclear inner membrane.,tissue specificity:Skeletal muscle, heart, colon, testis, ovary and pancreas.,
纯化
The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
