产品名称
GDI-2 Rabbit Polyclonal Antibody
别名
GDI2; RABGDIB; Rab GDP dissociation inhibitor beta; Rab GDI beta; Guanosine diphosphate dissociation inhibitor 2; GDI-2
蛋白名称
Rab GDP dissociation inhibitor beta
存储缓冲液
Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% New type preservative N.
Human Gene Link
http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=2665
Human Swissprot No.
P50395
Human Swissprot Link
http://www.uniprot.org/uniprotkb/P50395/entry
Mouse Gene Link
http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=14569
Mouse Swissprot No.
Q61598
Mouse Swissprot Link
http://www.uniprot.org/uniprot/Q61598
Rat Gene Link
http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=29662
Rat Swissprot Link
http://www.uniprot.org/uniprot/P50399
免疫原
Synthesized peptide derived from the C-terminal region of human GDI-2.
特异性
GDI-2 Polyclonal Antibody detects endogenous levels of GDI-2 protein.
稀释度
WB 1:500 - 1:2000. IHC-p: 1:100-1:300. ELISA: 1:20000.. IF 1:50-200
宿主
Polyclonal, Rabbit,IgG
背景介绍
GDP dissociation inhibitors are proteins that regulate the GDP-GTP exchange reaction of members of the rab family, small GTP-binding proteins of the ras superfamily, that are involved in vesicular trafficking of molecules between cellular organelles. GDIs slow the rate of dissociation of GDP from rab proteins and release GDP from membrane-bound rabs. GDI2 is ubiquitously expressed. The GDI2 gene contains many repetitive elements indicating that it may be prone to inversion/deletion rearrangements. Alternative splicing results in multiple transcript variants encoding distinct isoforms. [provided by RefSeq, Jul 2008],
细胞定位
Cytoplasm . Membrane ; Peripheral membrane protein .
功能
function:Regulates the GDP/GTP exchange reaction of most Rab proteins by inhibiting the dissociation of GDP from them, and the subsequent binding of GTP to them.,similarity:Belongs to the Rab GDI family.,tissue specificity:Ubiquitous.,
纯化
The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.