产品名称
CSTN2 Rabbit Polyclonal Antibody
别名
Calsyntenin-2 (Alcadein-gamma) (Alc-gamma)
存储缓冲液
Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.235% New type preservative N.
Human Gene Link
https://www.uniprot.org/uniprot/64084
Human Swissprot No.
Q9H4D0
Human Swissprot Link
https://www.uniprot.org/uniprotkb/Q9H4D0/entry
Mouse Gene Link
https://www.uniprot.org/uniprot/64085
Mouse Swissprot No.
Q9ER65
Mouse Swissprot Link
https://www.uniprot.org/uniprotkb/Q9ER65
Rat Gene Link
https://www.uniprot.org/uniprot/171394
Rat Swissprot Link
https://www.uniprot.org/uniprotkb/Q8VDA1
免疫原
Synthesized peptide derived from human CSTN2 AA range: 494-544
特异性
This antibody detects endogenous levels of CSTN2 at Human/Mouse/Rat
宿主
Polyclonal, Rabbit,IgG
组织表达
Restricted to the brain.
细胞定位
Cell membrane ; Single-pass type I membrane protein . Endoplasmic reticulum membrane . Golgi apparatus membrane . Cell junction, synapse, postsynapse . Cell projection, dendrite . Most prominent in the postsynaptic specializations of asymmetric (type I) synapses with both axodendritic and axospinous localization. .
功能
domain:Binds synaptic Ca(2+) with its cytoplasmic domain.,function:May modulate calcium-mediated postsynaptic signals.,PTM:Proteolytically processed under normal cellular conditions. A primary zeta-cleavage generates a large extracellular (soluble) N-terminal domain (sAlc) and a short C-terminal transmembrane fragment (CTF1). A secondary cleavage catalyzed by gamma-secretase within the transmembrane domain releases the beta-Alc-gamma chain in the extracellular milieu and produces an intracellular fragment (AlcICD). This processing is strongly suppressed in the tripartite complex formed with APBA2 and APP, which seems to prevent the association with PSEN1.,similarity:Contains 2 cadherin domains.,subcellular location:Most prominent in the postsynaptic specializations of asymmetric (type I) synapses with both axodendritic and axospinous localization.,tissue specificity:Restricted to the brain.,
纯化
The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
