产品名称
ARP Rabbit Polyclonal Antibody
别名
MANF; ARMET; ARP; Mesencephalic astrocyte-derived neurotrophic factor; Arginine-rich protein; Protein ARMET
蛋白名称
Mesencephalic astrocyte-derived neurotrophic factor
存储缓冲液
Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% New type preservative N.
Human Gene Link
http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=7873
Human Swissprot No.
P55145
Human Swissprot Link
http://www.uniprot.org/uniprotkb/P55145/entry
Mouse Swissprot No.
Q9CXI5
Mouse Swissprot Link
http://www.uniprot.org/uniprot/Q9CXI5
Rat Swissprot Link
http://www.uniprot.org/uniprot/P0C5H9
免疫原
The antiserum was produced against synthesized peptide derived from the Internal region of human MANF. AA range:11-60
特异性
ARP Polyclonal Antibody detects endogenous levels of ARP protein.
稀释度
WB 1:500 - 1:2000. IHC-p: 1:100-1:300. ELISA: 1:20000.. IF 1:50-200
宿主
Polyclonal, Rabbit,IgG
背景介绍
The protein encoded by this gene is localized in the endoplasmic reticulum (ER) and golgi, and is also secreted. Reducing expression of this gene increases susceptibility to ER stress-induced death and results in cell proliferation. Activity of this protein is important in promoting the survival of dopaminergic neurons. The presence of polymorphisms in the N-terminal arginine-rich region, including a specific mutation that changes an ATG start codon to AGG, have been reported in a variety of solid tumors; however, these polymorphisms were later shown to exist in normal tissues and are thus no longer thought to be tumor-related. [provided by RefSeq, Apr 2014],
细胞定位
Secreted . Endoplasmic reticulum lumen . Sarcoplasmic reticulum lumen . Retained in the endoplasmic reticulum (ER), and sarcoplasmic reticulum (SR) under normal conditions (PubMed:22637475). Up-regulated and secreted by the ER/SR in response to ER stress and hypoxia (PubMed:22637475, PubMed:29497057). .
功能
response to unfolded protein,?response to organic substance,?response to protein stimulus,
纯化
The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
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