BD-PT5320

NUMB Rabbit Polyclonal Antibody

NUMB; Protein numb homolog; h-Numb; Protein S171

常规抗体

NUMB

Protein numb homolog

WB

Human,Mouse,Rat

1 mg/ml

Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% New type preservative N.

8650

http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=8650

P49757

http://www.uniprot.org/uniprotkb/P49757/entry

18222

http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=18222

Q9QZS3

http://www.uniprot.org/uniprot/Q9QZS3

Q2LC84

http://www.uniprot.org/uniprot/Q2LC84

Synthesized peptide derived from the Internal region of human NUMB.

NUMB Polyclonal Antibody detects endogenous levels of NUMB protein.

WB 1:500-2000

70kD

-20°C/1 year

Polyclonal, Rabbit,IgG

The protein encoded by this gene plays a role in the determination of cell fates during development. The encoded protein, whose degradation is induced in a proteasome-dependent manner by MDM2, is a membrane-bound protein that has been shown to associate with EPS15, LNX1, and NOTCH1. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Feb 2016],

B cells,Blood,Brain,Cervix carcinoma,Epithelium,Fetal brain,HeLa cells,Live

Cell membrane ; Peripheral membrane protein ; Cytoplasmic side . Endosome membrane ; Peripheral membrane protein ; Cytoplasmic side . Localizes to perinuclear endosomes in an AAK1-dependent manner. .

Notch;

function:Implicated in the control of cell fate decisions during development.,PTM:Isoform 1 and isoform 2 are ubiquitinated by LNX leading to their subsequent proteasomal degradation (By similarity). Ubiquitinated; mediated by SIAH1 and leading to its subsequent proteasomal degradation.,sequence caution:Intron retention.,similarity:Contains 1 PID domain.,subunit:Interacts with EPS15, LNX and NOTCH1. May interact with DUOXA1. Interacts with RALBP1 in a complex also containing EPN1 and TFAP2A during interphase and mitosis.,

现货

The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.