产品名称
SYCM Rabbit Polyclonal Antibody
别名
Probable cysteine--tRNA ligase, mitochondrial (EC 6.1.1.16) (Cysteinyl-tRNA synthetase) (CysRS)
存储缓冲液
Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.121% New type preservative N.
Human Gene Link
https://www.uniprot.org/uniprot/79587
Human Swissprot No.
Q9HA77
Human Swissprot Link
https://www.uniprot.org/uniprotkb/Q9HA77/entry
Mouse Gene Link
https://www.uniprot.org/uniprot/71941
Mouse Swissprot No.
Q8BYM8
Mouse Swissprot Link
https://www.uniprot.org/uniprotkb/Q8BYM8
免疫原
Synthesized peptide derived from human SYCM AA range: 95-145
特异性
This antibody detects endogenous levels of SYCM at Human/Mouse
宿主
Polyclonal, Rabbit,IgG
背景介绍
This gene encodes a putative member of the class I family of aminoacyl-tRNA synthetases. These enzymes play a critical role in protein biosynthesis by charging tRNAs with their cognate amino acids. This protein is encoded by the nuclear genome but is likely to be imported to the mitochondrion where it is thought to catalyze the ligation of cysteine to tRNA molecules. A splice-site mutation in this gene has been associated with a novel progressive myoclonic epilepsy disease with similar symptoms to MERRF syndrome. [provided by RefSeq, Mar 2015],
组织表达
Colon adenocarcinoma,Lung,Lymph node,Mammary gland,Salivary gland,Testis,
细胞定位
Mitochondrion matrix .
功能
catalytic activity:ATP + L-cysteine + tRNA(Cys) = AMP + diphosphate + L-cysteinyl-tRNA(Cys).,cofactor:Binds 1 zinc ion per subunit.,similarity:Belongs to the class-I aminoacyl-tRNA synthetase family.,
纯化
The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
