产品名称
IL-28 Rabbit Polyclonal Antibody
别名
IL28A; IFNL2; ZCYTO20; Interleukin-28A; IL-28A; Cytokine Zcyto20; Interferon lambda-2; IFN-lambda-2
存储缓冲液
Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% New type preservative N.
Human Gene Link
http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=282616
Human Swissprot No.
Q8IZJ0
Human Swissprot Link
http://www.uniprot.org/uniprotkb/Q8IZJ0/entry
Mouse Gene Link
http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=330496
Mouse Swissprot No.
Q4VK74
Mouse Swissprot Link
http://www.uniprot.org/uniprot/Q4VK74
免疫原
The antiserum was produced against synthesized peptide derived from the C-terminal region of human IL28A. AA range:131-180
特异性
IL-28 Polyclonal Antibody detects endogenous levels of IL-28 protein.
稀释度
WB 1:500 - 1:2000. IHC-p: 1:100-1:300. ELISA: 1:20000.. IF 1:50-200
宿主
Polyclonal, Rabbit,IgG
背景介绍
This gene encodes a cytokine distantly related to type I interferons and the IL-10 family. This gene, interleukin 28B (IL28B), and interleukin 29 (IL29) are three closely related cytokine genes that form a cytokine gene cluster on a chromosomal region mapped to 19q13. Expression of the cytokines encoded by the three genes can be induced by viral infection. All three cytokines have been shown to interact with a heterodimeric class II cytokine receptor that consists of interleukin 10 receptor, beta (IL10RB) and interleukin 28 receptor, alpha (IL28RA). [provided by RefSeq, Jul 2008],
信号通路
Cytokine-cytokine receptor interaction;Jak_STAT;
功能
caution:It is uncertain whether Met-1 or Met-5 is the initiator.,function:Cytokine with immunomodulatory activity. Up-regulates MHC class I antigen expression. Displays potent antiviral activity. Also displays antitumor activity. Ligand for the heterodimeric class II cytokine receptor composed of IL10RB and IL28RA. The ligand/receptor complex seems to signal through the Jak-STAT pathway.,induction:By viral infections or double stranded RNA.,online information:Interleukin-28 entry,similarity:Belongs to the IL-28/IL-29 family.,
纯化
The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
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