产品名称
Inhibin β-E Rabbit Polyclonal Antibody
别名
INHBE; Inhibin beta E chain; Activin beta-E chain
蛋白名称
Inhibin beta E chain
存储缓冲液
Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% New type preservative N.
Human Gene Link
http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=83729
Human Swissprot No.
P58166
Human Swissprot Link
http://www.uniprot.org/uniprotkb/P58166/entry
Mouse Gene Link
http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=16326
Mouse Swissprot No.
O08717
Mouse Swissprot Link
http://www.uniprot.org/uniprot/O08717
Rat Gene Link
http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=83711
Rat Swissprot Link
http://www.uniprot.org/uniprot/O88959
免疫原
The antiserum was produced against synthesized peptide derived from the C-terminal region of human INHBE. AA range:301-350
特异性
Inhibin β-E Polyclonal Antibody detects endogenous levels of Inhibin β-E protein.
稀释度
WB 1:500 - 1:2000. IHC-p: 1:100-1:300. ELISA: 1:20000.. IF 1:50-200
宿主
Polyclonal, Rabbit,IgG
背景介绍
This gene encodes a member of the TGF-beta (transforming growth factor-beta) superfamily of proteins. The encoded preproprotein is proteolytically processed to generate an inhibin beta subunit. Inhibins have been implicated in regulating numerous cellular processes including cell proliferation, apoptosis, immune response and hormone secretion. This gene may be upregulated under conditions of endoplasmic reticulum stress, and this protein may inhibit cellular proliferation and growth in pancreas and liver. [provided by RefSeq, Sep 2016],
信号通路
Cytokine-cytokine receptor interaction;TGF-beta;
功能
function:Inhibins and activins inhibit and activate, respectively, the secretion of follitropin by the pituitary gland. Inhibins/activins are involved in regulating a number of diverse functions such as hypothalamic and pituitary hormone secretion, gonadal hormone secretion, germ cell development and maturation, erythroid differentiation, insulin secretion, nerve cell survival, embryonic axial development or bone growth, depending on their subunit composition. Inhibins appear to oppose the functions of activins.,similarity:Belongs to the TGF-beta family.,subunit:Homodimeric or heterodimeric through association with alpha and beta subunits, linked by one or more disulfide bonds. Inhibins are heterodimers of one alpha and one beta subunit. Activins are homo- or heterodimers of beta subunits only.,
纯化
The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.