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PDGF-D Rabbit Polyclonal Antibody

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产品基本信息

产品货号
BD-PT5299
产品名称
PDGF-D Rabbit Polyclonal Antibody
别名
PDGFD; IEGF; SCDGFB; MSTP036; Platelet-derived growth factor D; PDGF-D; Iris-expressed growth factor; Spinal cord-derived growth factor B; SCDGF-B
类别
常规抗体
基因名称
PDGFD
蛋白名称
Platelet-derived growth factor D
推荐应用
WB
反应种属
Human,Rat,Mouse
浓度
1 mg/ml
存储缓冲液
Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% New type preservative N.
Human Gene ID
80310
Human Gene Link
http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=80310
Human Swissprot No.
Q9GZP0
Human Swissprot Link
http://www.uniprot.org/uniprotkb/Q9GZP0/entry
Mouse Gene ID
71785
Mouse Gene Link
http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=71785
Mouse Swissprot No.
Q925I7
Mouse Swissprot Link
http://www.uniprot.org/uniprot/Q925I7
Rat Gene ID
66018
Rat Gene Link
http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=66018
Rat Swissprot No.
Q9EQT1
Rat Swissprot Link
http://www.uniprot.org/uniprot/Q9EQT1
免疫原
The antiserum was produced against synthesized peptide derived from the C-terminal region of human PDGFD. AA range:311-360
特异性
PDGF-D Polyclonal Antibody detects endogenous levels of PDGF-D protein.
稀释度
WB 1:500 - 1:2000. IHC-p: 1:100-1:300. ELISA: 1:20000.. IF 1:50-200
预测分子量
42kD
运输及保存条件
-20°C/1 year
宿主
Polyclonal, Rabbit,IgG
背景介绍
platelet derived growth factor D(PDGFD) Homo sapiens The protein encoded by this gene is a member of the platelet-derived growth factor family. The four members of this family are mitogenic factors for cells of mesenchymal origin and are characterized by a core motif of eight cysteines, seven of which are found in this factor. This gene product only forms homodimers and, therefore, does not dimerize with the other three family members. It differs from alpha and beta members of this family in having an unusual N-terminal domain, the CUB domain. Two splice variants have been identified for this gene. [provided by RefSeq, Jul 2008],
组织表达
Expressed at high levels in the heart, pancreas, adrenal gland and ovary and at low levels in placenta, liver, kidney, prostate, testis, small intestine, spleen and colon. In the kidney, expressed by the visceral epithelial cells of the glomeruli. A widespread expression is also seen in the medial smooth muscle cells of arteries and arterioles, as well as in smooth muscle cells of vasa rectae in the medullary area. Expressed in the adventitial connective tissue surrounding the suprarenal artery. In chronic obstructive nephropathy, a persistent expression is seen in glomerular visceral epithelial cells and vascular smooth muscle cells, as well as de novo expression by periglomerular interstitial cells and by some neointimal cells of atherosclerotic vessels. Expression in normal prostate is seen preferentially in the mesenchyme of the gland while expression is increased and more profuse in prostate carcinoma. Expressed in many ovarian, lung, renal and brain cancer-derived cell lines.
细胞定位
Secreted . Released by platelets upon wounding.
信号通路
Focal adhesion;Gap junction;Regulates Actin and Cytoskeleton;Prostate cancer;Melanoma;
功能
developmental stage:Not detectable in the earliest stages of glomerulogenesis, and not detected in the metanephric blastema or surrounding cortical interstitial cells. In later stages of glomerulogenesis, localized to epithelial cells transitioning from the early developing nephrons of the comma- and S-shaped stages to the visceral epithelial cells of differentiated glomeruli. In the developing pelvis, expressed at the basement membrane of immature collecting ducts and by presumptive fibroblastic cells in the interstitium.,function:Potent mitogen for cells of mesenchymal origin. Binding of this growth factor to its affinity receptor elicits a variety of cellular responses. It is released by platelets upon wounding and plays an important role in stimulating adjacent cells to grow and thereby heals the wound. Activated by proteolytic cleavage and this active form acts as a specific ligand for beta platelet-derived growth factor receptor. Induces macrophage recruitment, increased interstitial pressure, and blood vessel maturation during angiogenesis.,PTM:Proteolytic removal of the N-terminal CUB domain releasing the core domain is necessary for unmasking the receptor-binding epitopes of the core domain. Cleavage after Arg-247 or Arg-249 by urokinase plasminogen activator gives rise to the active form.,similarity:Belongs to the PDGF/VEGF growth factor family.,similarity:Contains 1 CUB domain.,subunit:Homodimer; disulfide-linked.,tissue specificity:Expressed at high levels in the heart, pancreas, adrenal gland and ovary and at low levels in placenta, liver, kidney, prostate, testis, small intestine, spleen and colon. In the kidney, expressed by the visceral epithelial cells of the glomeruli. A widespread expression is also seen in the medial smooth muscle cells of arteries and arterioles, as well as in smooth muscle cells of vasa rectae in the medullary area. Expressed in the adventitial connective tissue surrounding the suprarenal artery. In chronic obstructive nephropathy, a persistent expression is seen in glomerular visceral epithelial cells and vascular smooth muscle cells, as well as de novo expression by periglomerular interstitial cells and by some neointimal cells of arteriosclerotic vessels. Expression in normal prostate is seen preferentially in the mesenchyme of the gland while expression is increased and more profuse in prostate carcinoma. Expressed in many ovarian, lung, renal and brain cancer-derived cell lines.,
期货
现货
纯化
The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.

Western blot analysis of lysate from L929 cells, using PDGFD Antibody.

Western Blot analysis of L929 cells using PDGF-D Polyclonal Antibody.. Secondary antibody was diluted at 1:20000

Immunohistochemical analysis of paraffin-embedded human-mammary-cancer, antibody was diluted at 1:100

Immunohistochemical analysis of paraffin-embedded human-lung-cancer, antibody was diluted at 1:100

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