产品名称
CSTN3 Rabbit Polyclonal Antibody
别名
Calsyntenin-3 (Alcadein-beta) (Alc-beta)
存储缓冲液
Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.237% New type preservative N.
Human Gene Link
https://www.uniprot.org/uniprot/9746
Human Swissprot No.
Q9BQT9
Human Swissprot Link
https://www.uniprot.org/uniprotkb/Q9BQT9/entry
Mouse Gene Link
https://www.uniprot.org/uniprot/232370
Mouse Swissprot No.
Q99JH7
Mouse Swissprot Link
https://www.uniprot.org/uniprotkb/Q99JH7
Rat Gene Link
https://www.uniprot.org/uniprot/171393
Rat Swissprot Link
https://www.uniprot.org/uniprotkb/Q8R553
免疫原
Synthesized peptide derived from human CSTN3 AA range: 660-710
特异性
This antibody detects endogenous levels of CSTN3 at Human/Mouse/Rat
宿主
Polyclonal, Rabbit,IgG
组织表达
According to PubMed:12498782, expressed predominantly in the brain and in kidney. Low levels in heart, skeletal muscle, liver, placenta, pancreas and lung. According to PubMed:12972431, predominant expression in brain, and only marginal in kidney. In brain, present throughout all cortical layers, highest levels in GABAergic neurons (based on morphology and distribution pattern).
细胞定位
Cell membrane ; Single-pass type I membrane protein . Endoplasmic reticulum membrane . Golgi apparatus membrane . Cell junction, synapse, postsynapse . Cell projection, dendrite . Most prominent in the postsynaptic specializations of asymmetric (type I) synapses with both axodendritic and axospinous localization. .
功能
domain:Binds synaptic Ca(2+) with its cytoplasmic domain.,function:May modulate calcium-mediated postsynaptic signals (By similarity). Complex formation with APBA2 and APP, stabilizes APP metabolism and enhances APBA2-mediated suppression of beta-APP40 secretion, due to the retardation of intracellular APP maturation.,PTM:Proteolytically processed under normal cellular conditions. A primary zeta-cleavage generates a large extracellular (soluble) N-terminal domain (sAlc) and a short C-terminal transmembrane fragment (CTF1). A secondary cleavage catalyzed by gamma-secretase within the transmembrane domain releases the beta-Alc-beta chain in the extracellular milieu and produces an intracellular fragment (AlcICD). This processing is strongly suppressed in the tripartite complex formed with APBA2 and APP, which seems to prevent the association with gamma-secretase.,similarity:Contains 2 cadherin domains.,subcellular location:Most prominent in the postsynaptic specializations of asymmetric (type I) synapses with both axodendritic and axospinous localization.,subunit:Directly interacts with APBA2. Forms a tripartite complex with APBA2 and APP. Interacts with low affinity with KLC1.,tissue specificity:Expressed predominantly in the brain and in kidney. Low levels in heart, skeletal muscle, liver, placenta, pancreas and lung (in PubMed:12498782). Predominant expression in brain, and only marginal in kidney (in PubMed:12972431). In brain, present throughout all cortical layers, highest levels in GABAergic neurons (based on morphology and distribution pattern).,
纯化
The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
