产品名称
MACC1 Rabbit Polyclonal Antibody
别名
MACC1; Metastasis-associated in colon cancer protein 1; SH3 domain-containing protein 7a5
蛋白名称
Metastasis-associated in colon cancer protein 1
存储缓冲液
Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% New type preservative N.
Human Gene Link
http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=346389
Human Swissprot No.
Q6ZN28
Human Swissprot Link
http://www.uniprot.org/uniprotkb/Q6ZN28/entry
免疫原
The antiserum was produced against synthesized peptide derived from the Internal region of human MACC1. AA range:411-460
特异性
MACC1 Polyclonal Antibody detects endogenous levels of MACC1 protein.
稀释度
WB 1:500 - 1:2000. ELISA: 1:20000. Not yet tested in other applications.
宿主
Polyclonal, Rabbit,IgG
背景介绍
MACC1 is a key regulator of the hepatocyte growth factor (HGF; MIM 142409)-HGF receptor (HGFR, or MET; MIM 164860) pathway, which is involved in cellular growth, epithelial-mesenchymal transition, angiogenesis, cell motility, invasiveness, and metastasis. Expression of MACC1 in colon cancer (MIM 114500) specimens is an independent prognostic indicator for metastasis formation and metastasis-free survival (Stein et al., 2009 [PubMed 19098908]).[supplied by OMIM, Mar 2009],
组织表达
Preferentially expressed in metastasizing tumors.
细胞定位
Cytoplasm . Nucleus . Mainly found in the cytoplasm in non-metastasizing tumors.
功能
function:Acts as a transcription activator for MET and as a key regulator of HGF-MET signaling. Promotes cell motility, proliferation and hepatocyte growth factor (HGF)-dependent scattering in vitro and tumor growth and metastasis in vivo.,similarity:Contains 1 SH3 domain.,subcellular location:Mainly found in the cytoplasm in non-metastasizing tumors.,tissue specificity:Preferentially expressed in metastasizing tumors.,
纯化
The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
