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CKR-4 Rabbit Polyclonal Antibody

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产品基本信息

产品货号
BD-PT5290
产品名称
CKR-4 Rabbit Polyclonal Antibody
别名
CCR4; CMKBR4; C-C chemokine receptor type 4; C-C CKR-4; CC-CKR-4; CCR-4; CCR4; K5-5; CD194
类别
常规抗体
基因名称
CCR4
蛋白名称
C-C chemokine receptor type 4
推荐应用
WB
反应种属
Human,Mouse,Rat
浓度
1 mg/ml
存储缓冲液
Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% New type preservative N.
Human Gene ID
1233
Human Gene Link
http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=1233
Human Swissprot No.
P51679
Human Swissprot Link
http://www.uniprot.org/uniprotkb/P51679/entry
Mouse Gene ID
12773
Mouse Gene Link
http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=12773
Mouse Swissprot No.
P51680
Mouse Swissprot Link
http://www.uniprot.org/uniprot/P51680
免疫原
The antiserum was produced against synthesized peptide derived from the N-terminal region of human CCR4. AA range:1-50
特异性
CKR-4 Polyclonal Antibody detects endogenous levels of CKR-4 protein.
稀释度
WB 1:500 - 1:2000. IHC-p: 1:100-300 ELISA: 1:20000.. IF 1:50-200
预测分子量
41kD
运输及保存条件
-20°C/1 year
宿主
Polyclonal, Rabbit,IgG
背景介绍
The protein encoded by this gene belongs to the G-protein-coupled receptor family . It is a receptor for the CC chemokine - MIP-1, RANTES, TARC and MCP-1. Chemokines are a group of small polypeptide, structurally related molecules that regulate cell trafficking of various types of leukocytes. The chemokines also play fundamental roles in the development, homeostasis, and function of the immune system, and they have effects on cells of the central nervous system as well as on endothelial cells involved in angiogenesis or angiostasis. [provided by RefSeq, Jul 2008],
组织表达
Predominantly expressed in the thymus, in peripheral blood leukocytes, including T-cells, mostly CD4+ cells, and basophils, and in platelets; at lower levels, in the spleen and in monocytes. Detected also in macrophages, IL-2-activated natural killer cells and skin-homing memory T-cells, mostly the ones expressing the cutaneous lymphocyte antigen (CLA). Expressed in brain microvascular and coronary artery endothelial cells.
细胞定位
Cell membrane; Multi-pass membrane protein.
信号通路
Cytokine-cytokine receptor interaction;Chemokine;
功能
function:High affinity receptor for the C-C type chemokines CCL17/TARC and CCL22/MDC. The activity of this receptor is mediated by G(i) proteins which activate a phosphatidylinositol-calcium second messenger system. Can function as a chemoattractant homing receptor on circulating memory lymphocytes and as a coreceptor for some primary HIV-2 isolates. In the CNS, could mediate hippocampal-neuron survival.,online information:CC chemokine receptors entry,PTM:In natural killer cells, CCL22 binding induces phosphorylation on yet undefined Ser/Thr residues, most probably by beta-adrenergic receptor kinases 1 and 2.,similarity:Belongs to the G-protein coupled receptor 1 family.,tissue specificity:Predominantly expressed in the thymus, in peripheral blood leukocytes, including T-cells, mostly CD4+ cells, and basophils, and in platelets; at lower levels, in the spleen and in monocytes. Detected also in macrophages, IL-2-activated natural killer cells and skin-homing memory T-cells, mostly the ones expressing the cutaneous lymphocyte antigen (CLA). Expressed in brain microvascular and coronary artery endothelial cells.,
期货
现货
纯化
The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.

Western blot analysis of lysate from L929 cells, using CCR4 Antibody.

Western Blot analysis of L929 cells using CKR-4 Polyclonal Antibody.. Secondary antibody was diluted at 1:20000

Immunohistochemical analysis of paraffin-embedded mouse-spleen, antibody was diluted at 1:100

Immunohistochemical analysis of paraffin-embedded mouse-spleen, antibody was diluted at 1:100

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