产品名称
CKR-3 Rabbit Polyclonal Antibody
别名
CCR3; CMKBR3; C-C chemokine receptor type 3; C-C CKR-3; CC-CKR-3; CCR-3; CCR3; CKR3; Eosinophil eotaxin receptor; CD193
蛋白名称
C-C chemokine receptor type 3
存储缓冲液
Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% New type preservative N.
Human Gene Link
http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=1232
Human Swissprot No.
P51677
Human Swissprot Link
http://www.uniprot.org/uniprotkb/P51677/entry
Mouse Gene Link
http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=12771
Mouse Swissprot No.
P51678
Mouse Swissprot Link
http://www.uniprot.org/uniprot/P51678
Rat Gene Link
http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=117027
Rat Swissprot Link
http://www.uniprot.org/uniprot/O54814
免疫原
The antiserum was produced against synthesized peptide derived from the N-terminal region of human CCR3. AA range:1-50
特异性
CKR-3 Polyclonal Antibody detects endogenous levels of CKR-3 protein.
稀释度
WB 1:500 - 1:2000. IHC-p: 1:100-300 ELISA: 1:20000.. IF 1:50-200
宿主
Polyclonal, Rabbit,IgG
背景介绍
The protein encoded by this gene is a receptor for C-C type chemokines. It belongs to family 1 of the G protein-coupled receptors. This receptor binds and responds to a variety of chemokines, including eotaxin (CCL11), eotaxin-3 (CCL26), MCP-3 (CCL7), MCP-4 (CCL13), and RANTES (CCL5). It is highly expressed in eosinophils and basophils, and is also detected in TH1 and TH2 cells, as well as in airway epithelial cells. This receptor may contribute to the accumulation and activation of eosinophils and other inflammatory cells in the allergic airway. It is also known to be an entry co-receptor for HIV-1. This gene and seven other chemokine receptor genes form a chemokine receptor gene cluster on the chromosomal region 3p21. Alternatively spliced transcript variants have been described. [provided by RefSeq, Sep 2009],
组织表达
In eosinophils as well as trace amounts in neutrophils and monocytes.
细胞定位
Cell membrane; Multi-pass membrane protein .
信号通路
Cytokine-cytokine receptor interaction;Chemokine;
功能
function:Receptor for a C-C type chemokine. Binds to eotaxin, eotaxin-3, MCP-3, MCP-4, RANTES and MIP-1 delta. Subsequently transduces a signal by increasing the intracellular calcium ions level. Alternative coreceptor with CD4 for HIV-1 infection.,online information:CC chemokine receptors entry,similarity:Belongs to the G-protein coupled receptor 1 family.,subunit:Binds to HIV-1 Tat.,tissue specificity:In eosinophils as well as trace amounts in neutrophils and monocytes.,
纯化
The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
