产品名称
CD201 Rabbit Polyclonal Antibody
别名
PROCR; EPCR; Endothelial protein C receptor; Activated protein C receptor; APC receptor; Endothelial cell protein C receptor; CD201
蛋白名称
Endothelial protein C receptor
存储缓冲液
Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% New type preservative N.
Human Gene Link
http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=10544
Human Swissprot No.
Q9UNN8
Human Swissprot Link
http://www.uniprot.org/uniprotkb/Q9UNN8/entry
Mouse Gene Link
http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=19124
Mouse Swissprot No.
Q64695
Mouse Swissprot Link
http://www.uniprot.org/uniprot/Q64695
Rat Gene Link
http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=362248
Rat Swissprot Link
http://www.uniprot.org/uniprot/Q4V8I1
免疫原
Synthesized peptide derived from Endothelial protein C receptor at AA range: 141-190
特异性
CD201 Polyclonal Antibody detects endogenous levels of CD201 protein.
稀释度
WB 1:500 - 1:2000. IHC-p: 1:100-300 ELISA: 1:20000.. IF 1:50-200
宿主
Polyclonal, Rabbit,IgG
背景介绍
The protein encoded by this gene is a receptor for activated protein C, a serine protease activated by and involved in the blood coagulation pathway. The encoded protein is an N-glycosylated type I membrane protein that enhances the activation of protein C. Mutations in this gene have been associated with venous thromboembolism and myocardial infarction, as well as with late fetal loss during pregnancy. The encoded protein may also play a role in malarial infection and has been associated with cancer. [provided by RefSeq, Jul 2013],
组织表达
Expressed strongly in the endothelial cells of arteries and veins in heart and lung, less intensely in capillaries in the lung and skin, and not at all in the endothelium of small vessels of the liver and kidney.
细胞定位
Membrane; Single-pass type I membrane protein.
功能
function:Binds activated protein C. Enhances protein C activation by the thrombin-thrombomodulin complex; plays a role in the protein C pathway controlling blood coagulation.,PTM:A soluble form exists; probably released by a metalloprotease. Seems to have the same activity as the membrane-bound form.,PTM:N-glycosylated.,tissue specificity:Expressed strongly in the endothelial cells of arteries and veins in heart and lung, less intensely in capillaries in the lung and skin, and not at all in the endothelium of small vessels of the liver and kidney.,
纯化
The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
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