产品名称
NPNT Rabbit Polyclonal Antibody
别名
Nephronectin (Preosteoblast EGF-like repeat protein with MAM domain) (Protein EGFL6-like)
基因名称
NPNT EGFL6L POEM UNQ295/PRO334
存储缓冲液
Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.126% New type preservative N.
Human Gene Link
https://www.uniprot.org/uniprot/255743
Human Swissprot No.
Q6UXI9
Human Swissprot Link
https://www.uniprot.org/uniprotkb/Q6UXI9/entry
Mouse Gene Link
https://www.uniprot.org/uniprot/114249
Mouse Swissprot No.
Q91V88
Mouse Swissprot Link
https://www.uniprot.org/uniprotkb/Q91V88
免疫原
Synthesized peptide derived from human NPNT AA range: 485-535
特异性
This antibody detects endogenous levels of NPNT at Human/Mouse
宿主
Polyclonal, Rabbit,IgG
组织表达
Expressed in kidney and lung and to a lower extent in brain, pregnant uterus, placenta, thyroid gland and blood vessels.
细胞定位
Secreted, extracellular space, extracellular matrix . Trapped on the cell surface or in the extracellular matrix. .
功能
developmental stage:Expressed in fetal kidney, cochlea, eye, heart and lung.,domain:The MAM domain is required for localization at the cell surface.,function:Functional ligand of integrin alpha-8/beta-1 in kidney development. Regulates the expression of GDNF with integrin alpha-8/beta-1 which is essential for kidney development. May also play a role in the development and function of various tissues, regulating cell adhesion, spreading and survival through the binding of several integrins.,similarity:Belongs to the nephronectin family.,similarity:Contains 1 MAM domain.,similarity:Contains 5 EGF-like domains.,subcellular location:Trapped on the cell surface or in the extracellular matrix.,subunit:Homodimer and homotrimer.,tissue specificity:Expressed in kidney and lung and to a lower extent in brain, pregnant uterus, placenta, thyroid gland and blood vessels.,
纯化
The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
