产品名称
UBP21 Rabbit Polyclonal Antibody
别名
Ubiquitin carboxyl-terminal hydrolase 21 (EC 3.4.19.12) (Deubiquitinating enzyme 21) (Ubiquitin thioesterase 21) (Ubiquitin-specific-processing protease 21)
存储缓冲液
Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.129% New type preservative N.
Human Gene Link
https://www.uniprot.org/uniprot/27005
Human Swissprot No.
Q9UK80
Human Swissprot Link
https://www.uniprot.org/uniprotkb/Q9UK80/entry
Mouse Gene Link
https://www.uniprot.org/uniprot/30941
Mouse Swissprot No.
Q9QZL6
Mouse Swissprot Link
https://www.uniprot.org/uniprotkb/Q9QZL6
Rat Gene Link
https://www.uniprot.org/uniprot/688466
Rat Swissprot Link
https://www.uniprot.org/uniprotkb/B2GUX4
免疫原
Synthesized peptide derived from human UBP21 AA range: 50-100
特异性
This antibody detects endogenous levels of UBP21 at Human/Mouse/Rat
宿主
Polyclonal, Rabbit,IgG
背景介绍
This gene encodes a member of the C19 peptidase family, also known as family 2 of ubiquitin carboxy-terminal hydrolases. The encoded protein cleaves ubiquitin from ubiquitinated proteins for recycling in intracellular protein degradation. The encoded protein is also able to release NEDD8, a ubiquitin-like protein, from NEDD8-conjugated proteins. This gene has been referred to as USP16 and USP23 but is now known as USP21. Alternatively spliced transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Feb 2016],
组织表达
Highly expressed in heart, pancreas and skeletal muscle. Also expressed in brain, placenta, liver and kidney, and at very low level in lung.
细胞定位
Cytoplasm . Nucleus .
功能
catalytic activity:Ubiquitin C-terminal thioester + H(2)O = ubiquitin + a thiol.,function:Deubiquitinates histone H2A, a specific tag for epigenetic transcriptional repression, thereby acting as a coactivator. Deubiquitination of histone H2A releaves the repression of di- and trimethylation of histone H3 at 'Lys-4', resulting in regulation of transcriptional initiation. Regulates gene expression via histone H2A deubiquitination (By similarity). Also capable of removing NEDD8 from NEDD8 conjugates but has no effect on Sentrin-1 conjugates.,similarity:Belongs to the peptidase C19 family. USP21 subfamily.,tissue specificity:Highly expressed in heart, pancreas and skeletal muscle. Also expressed in brain, placenta, liver and kidney, and at very low level in lung.,
纯化
The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
