BD-PT5261

Nectin 3 Rabbit Polyclonal Antibody

PVRL3; PRR3; Poliovirus receptor-related protein 3; CDw113; Nectin-3; CD113

常规抗体

PVRL3

Poliovirus receptor-related protein 3

WB

Human,Mouse,Rat

1 mg/ml

Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% New type preservative N.

25945

http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=25945

Q9NQS3

http://www.uniprot.org/uniprotkb/Q9NQS3/entry

58998

http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=58998

Q9JLB9

http://www.uniprot.org/uniprot/Q9JLB9

The antiserum was produced against synthesized peptide derived from the Internal region of human PVRL3. AA range:311-360

Nectin 3 Polyclonal Antibody detects endogenous levels of Nectin 3 protein.

WB 1:500 - 1:2000. ELISA: 1:20000. Not yet tested in other applications.

60kD

-20°C/1 year

Polyclonal, Rabbit,IgG

This gene encodes a member of the nectin family of proteins, which function as adhesion molecules at adherens junctions. This family member interacts with other nectin-like proteins and with afadin, a filamentous actin-binding protein involved in the regulation of directional motility, cell proliferation and survival. This gene plays a role in ocular development involving the ciliary body. Mutations in this gene are believed to result in congenital ocular defects. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Aug 2011],

Predominantly expressed in testis and placenta as well as in many cell lines, including epithelial cell lines.

Cell membrane ; Single-pass membrane protein . Cell junction, synapse, postsynaptic cell membrane .

Cell adhesion molecules (CAMs);Adherens_Junction;

function:Plays a role in cell-cell adhesion through heterophilic trans-interactions with nectin-like proteins or nectins, such as trans-interaction with PVRL2/nectin-2 at Sertoli-spermatid junctions. Trans-interaction with PVR induces activation of CDC42 and RAC small G proteins through common signaling molecules such as SRC and RAP1. Also involved in the formation of cell-cell junctions, including adherens junctions and synapses. Induces endocytosis-mediated down-regulation of PVR from the cell surface, resulting in reduction of cell movement and proliferation. Plays a role in the morphology of the ciliary body.,similarity:Belongs to the nectin family.,similarity:Contains 1 Ig-like V-type (immunoglobulin-like) domain.,similarity:Contains 2 Ig-like C2-type (immunoglobulin-like) domains.,subunit:Cis- and trans-homodimer. Can form trans-heterodimers with PVRL1/nectin-1, PVRL2/nectin-2, PVR, IGSF4B/Necl-1 and with IGSF4. Interacts with MLLT4/afadin. Binds with low affinity to TIGIT.,tissue specificity:Predominantly expressed in testis and placenta as well as in many cell lines, including epithelial cell lines.,

现货

The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.