产品名称
CD73 Rabbit Polyclonal Antibody
别名
NT5E; NT5; NTE; 5'-nucleotidase; 5'-NT; Ecto-5'-nucleotidase; CD73
存储缓冲液
Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% New type preservative N.
Human Gene Link
http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=4907
Human Swissprot No.
P21589
Human Swissprot Link
http://www.uniprot.org/uniprotkb/P21589/entry
Mouse Swissprot No.
Q61503
Mouse Swissprot Link
http://www.uniprot.org/uniprot/Q61503
免疫原
The antiserum was produced against synthesized peptide derived from the Internal region of human NT5E. AA range:431-480
特异性
CD73 Polyclonal Antibody detects endogenous levels of CD73 protein.
稀释度
WB 1:500 - 1:2000. IHC-p: 1:100-300 ELISA: 1:20000.. IF 1:50-200
宿主
Polyclonal, Rabbit,IgG
背景介绍
The protein encoded by this gene is a plasma membrane protein that catalyzes the conversion of extracellular nucleotides to membrane-permeable nucleosides. The encoded protein is used as a determinant of lymphocyte differentiation. Defects in this gene can lead to the calcification of joints and arteries. Two transcript variants encoding different isoforms have been found for this gene.[provided by RefSeq, Mar 2011],
组织表达
Leukocyte,Liver,Placenta,Skin,
细胞定位
Cell membrane ; Lipid-anchor, GPI-anchor .
信号通路
Purine metabolism;Pyrimidine metabolism;Nicotinate and nicotinamide metabolism;
功能
catalytic activity:A 5'-ribonucleotide + H(2)O = a ribonucleoside + phosphate.,cofactor:Zinc.,disease:There is a decrease in the activity of NT5 in B-cell chronic lymphocytic leukemia.,function:Hydrolyzes extracellular nucleotides into membrane permeable nucleosides.,similarity:Belongs to the 5'-nucleotidase family.,subunit:Homodimer; disulfide-linked.,
纯化
The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
