产品名称
CD48 Rabbit Polyclonal Antibody
别名
CD48; BCM1; BLAST1; CD48 antigen; B-lymphocyte activation marker BLAST-1; BCM1 surface antigen; Leukocyte antigen MEM-102; TCT.1; CD48
存储缓冲液
Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% New type preservative N.
Human Gene Link
http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=962
Human Swissprot No.
P09326
Human Swissprot Link
http://www.uniprot.org/uniprotkb/P09326/entry
Mouse Swissprot No.
P18181
Mouse Swissprot Link
http://www.uniprot.org/uniprot/P18181
免疫原
The antiserum was produced against synthesized peptide derived from the Internal region of human CD48. AA range:41-90
特异性
CD48 Polyclonal Antibody detects endogenous levels of CD48 protein.
稀释度
WB 1:500 - 1:2000. IHC-p: 1:100-300 ELISA: 1:20000.. IF 1:50-200
宿主
Polyclonal, Rabbit,IgG
背景介绍
This gene encodes a member of the CD2 subfamily of immunoglobulin-like receptors which includes SLAM (signaling lymphocyte activation molecules) proteins. The encoded protein is found on the surface of lymphocytes and other immune cells, dendritic cells and endothelial cells, and participates in activation and differentiation pathways in these cells. The encoded protein does not have a transmembrane domain, however, but is held at the cell surface by a GPI anchor via a C-terminal domain which maybe cleaved to yield a soluble form of the receptor. Multiple transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Dec 2011],
组织表达
Widely expressed on all hematopoietic cells.
细胞定位
Cell membrane ; Lipid-anchor, GPI-anchor . Secreted .
信号通路
Natural killer cell mediated cytotoxicity;
功能
function:Ligand for CD2. Might facilitate interaction between activated lymphocytes. Probably involved in regulating T-cell activation.,similarity:Contains 1 Ig-like C2-type (immunoglobulin-like) domain.,similarity:Contains 1 Ig-like V-type (immunoglobulin-like) domain.,
纯化
The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.