产品名称
FBXW5 Rabbit Polyclonal Antibody
别名
F-box/WD repeat-containing protein 5 (F-box and WD-40 domain-containing protein 5)
存储缓冲液
Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.132% New type preservative N.
Human Gene Link
https://www.uniprot.org/uniprot/54461
Human Swissprot No.
Q969U6
Human Swissprot Link
https://www.uniprot.org/uniprotkb/Q969U6/entry
Mouse Gene Link
https://www.uniprot.org/uniprot/30839
Mouse Swissprot No.
Q9QXW2
Mouse Swissprot Link
https://www.uniprot.org/uniprotkb/Q9QXW2
Rat Gene Link
https://www.uniprot.org/uniprot/362081
Rat Swissprot Link
https://www.uniprot.org/uniprotkb/Q4KLI9
免疫原
Synthesized peptide derived from human FBXW5 AA range: 319-369
特异性
This antibody detects endogenous levels of FBXW5 at Human/Mouse/Rat
宿主
Polyclonal, Rabbit,IgG
背景介绍
This gene encodes a member of the F-box protein family, members of which are characterized by an approximately 40 amino acid motif, the F-box. The F-box proteins constitute one of the four subunits of ubiquitin protein ligase complex called SCFs (SKP1-cullin-F-box), which function in phosphorylation-dependent ubiquitination. The F-box proteins are divided into three classes: Fbws containing WD-40 domains, Fbls containing leucine-rich repeats, and Fbxs containing either different protein-protein interaction modules or no recognizable motifs. The protein encoded by this gene contains WD-40 domains, in addition to an F-box motif, so it belongs to the Fbw class. Alternatively spliced transcript variants encoding distinct isoforms have been identified for this gene, however, they were found to be nonsense-mediated mRNA decay (NMD) candidates, hence not represented. [provided by RefSeq, Jul 2008],
组织表达
Brain,Cervix,Colon,Ovary,Placenta,Skin,Testis,
功能
function:Substrate-recognition component of the SCF (SKP1-CUL1-F-box protein)-type E3 ubiquitin ligase complex.,similarity:Contains 1 F-box domain.,similarity:Contains 3 WD repeats.,subunit:Interacts with SKP1A and CUL1.,
纯化
The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
