产品名称
TFPI Rabbit Polyclonal Antibody
别名
TFPI; LACI; TFPI1; Tissue factor pathway inhibitor; TFPI; Extrinsic pathway inhibitor; EPI; Lipoprotein-associated coagulation inhibitor; LACI
蛋白名称
Tissue factor pathway inhibitor
存储缓冲液
Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% New type preservative N.
Human Gene Link
http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=7035
Human Swissprot No.
P10646
Human Swissprot Link
http://www.uniprot.org/uniprotkb/P10646/entry
Mouse Swissprot No.
O54819
Mouse Swissprot Link
http://www.uniprot.org/uniprot/O54819
免疫原
The antiserum was produced against synthesized peptide derived from the C-terminal region of human TFPI. AA range:251-300
特异性
TFPI Polyclonal Antibody detects endogenous levels of TFPI protein.
稀释度
WB 1:500 - 1:2000. ELISA: 1:20000. Not yet tested in other applications.
宿主
Polyclonal, Rabbit,IgG
背景介绍
This gene encodes a Kunitz-type serine protease inhibitor that regulates the tissue factor (TF)-dependent pathway of blood coagulation. The coagulation process initiates with the formation of a factor VIIa-TF complex, which proteolytically activates additional proteases (factors IX and X) and ultimately leads to the formation of a fibrin clot. The product of this gene inhibits the activated factor X and VIIa-TF proteases in an autoregulatory loop. Inhibition of the encoded protein restores hemostasis in animal models of hemophilia. This gene encodes multiple protein isoforms that differ in their inhibitory activity, specificity and cellular localization. [provided by RefSeq, Jul 2016],
组织表达
Mostly in endothelial cells.
细胞定位
[Isoform Alpha]: Secreted.; [Isoform Beta]: Microsome membrane ; Lipid-anchor, GPI-anchor .
信号通路
Complement and coagulation cascades;
功能
domain:This inhibitor contains three inhibitory domains. The first domain interacts with VIIa and TF, the second one with Xa.,function:Inhibits factor X (X(a)) directly and, in a Xa-dependent way, inhibits VIIa/tissue factor activity, presumably by forming a quaternary Xa/LACI/VIIa/TF complex. It possesses an antithrombotic action and also the ability to associate with lipoproteins in plasma.,online information:TFPI entry,PTM:O-glycosylated.,similarity:Contains 2 BPTI/Kunitz inhibitor domains.,similarity:Contains 3 BPTI/Kunitz inhibitor domains.,tissue specificity:Mostly in endothelial cells.,
纯化
The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
