产品名称
MCLN2 Rabbit Polyclonal Antibody
存储缓冲液
Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.134% New type preservative N.
Human Gene Link
https://www.uniprot.org/uniprot/255231
Human Swissprot No.
Q8IZK6
Human Swissprot Link
https://www.uniprot.org/uniprotkb/Q8IZK6/entry
Mouse Gene Link
https://www.uniprot.org/uniprot/68279
Mouse Swissprot No.
Q8K595
Mouse Swissprot Link
https://www.uniprot.org/uniprotkb/Q8K595
免疫原
Synthesized peptide derived from human MCLN2 AA range: 328-378
特异性
This antibody detects endogenous levels of MCLN2 at Human/Mouse
宿主
Polyclonal, Rabbit,IgG
背景介绍
Mucolipins constitute a family of cation channel proteins with homology to the transient receptor potential superfamily. In mammals, the mucolipin family includes 3 members, MCOLN1 (MIM 605248), MCOLN2, and MCOLN3 (MIM 607400), that exhibit a common 6-membrane-spanning topology. Homologs of mammalian mucolipins exist in Drosophila and C. elegans. Mutations in the human MCOLN1 gene cause mucolipodosis IV (MIM 262650) (Karacsonyi et al., 2007 [PubMed 17662026]).[supplied by OMIM, Sep 2009],
细胞定位
Cell membrane ; Multi-pass membrane protein . Late endosome membrane ; Multi-pass membrane protein . Lysosome membrane ; Multi-pass membrane protein . Recycling endosome membrane ; Multi-pass membrane protein . Localizes to recycling endosomes in activated macrophages and microglia. .
功能
sequence caution:Translated as Trp.,similarity:Belongs to the transient receptor family. Polycystin subfamily.,
纯化
The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
